短链脂肪酸对肠黏膜稳态免疫调节作用的研究进展

发布时间：2018-05-03 04:00

本文选题：短链脂肪酸 + 肠黏膜免疫　；参考：《免疫学杂志》2017年10期

【摘要】：短链脂肪酸(SCFAs)是一类碳原子少于6个的脂肪酸,主要由饮食中纤维成分经肠道菌群酵解产生,肠道中含量较多的为乙酸(C2)、丙酸(C3)、丁酸(C4)。它们能通过影响不同免疫细胞的功能参与肠道黏膜免疫反应,维持肠道稳态。目前研究发现,它们可通过识别Toll样受体(TLRs),活化G蛋白偶联受体(GPCRs),抑制组蛋白去乙酰酶(HDAC)活性等参与肠道疾病的发生发展。本文就短链脂肪酸对肠黏膜稳态的免疫调节作用做一综述。
[Abstract]:Short chain fatty acid (SCFAsS) is a kind of fatty acids with less than 6 carbon atoms, which is mainly produced by the fermentation of dietary fiber by intestinal microflora. The main contents of SCFAsS in the intestines are C _ 2C _ (2) acetate, C _ (3) C _ (3) propionate and C _ (4) C _ (4) butyrate. They can participate in the intestinal mucosal immune response by affecting the function of different immune cells and maintain the intestinal homeostasis. It has been found that they can be involved in the occurrence and development of intestinal diseases by recognizing TLRsN, activating G-protein-coupled receptor (GPCRsN) and inhibiting the activity of histone deacetylase (histone deacetylase). This article reviews the immunoregulatory effects of short chain fatty acids on intestinal mucosal homeostasis.
【作者单位】：同济大学附属第十人民医院消化内科;
【基金】：国家自然科学基金(81630017) 上海市青年科技英才扬帆计划(17YF1414700)
【分类号】：R392

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