P53信号蛋白动力学研究进展

发布时间：2018-05-03 15:50

本文选题：P + 动力学行为　；参考：《现代预防医学》2017年02期

【摘要】：长期以来,人们对生物信号蛋白的研究一直停留在对其信号通路,即信号蛋白与其上下游因子构成的网络结构这一层面。信号蛋白动力学的出现标志着人类对信号分子的认识达到了一个新的层次,使得人们对信号网络的认知实现从"静态"到"动态"的飞跃。作为重要的细胞命运决策者,P53蛋白的动力学行为是近年来分子生物学及系统生物学领域研究的热点。本文综述了P53蛋白动力学行为的最新研究成果,分析了构成P53动力学行为的分子结构基础及其对应的生物学功能,提出了P53蛋白动力学的深入研究方向。
[Abstract]:For a long time, the study of biological signal protein has been focused on the signal pathway, that is, the network structure of signal protein and its upstream and downstream factors. The emergence of signal protein dynamics marks a new level of human understanding of signal molecules, which makes people realize the leap from "static" to "dynamic" in the cognition of signal networks. As an important decision maker of cell fate, the kinetic behavior of p53 protein has been a hot topic in molecular biology and systems biology in recent years. In this paper, the latest research achievements on the kinetic behavior of p53 protein are reviewed. The molecular structure and corresponding biological functions of p53 protein kinetic behavior are analyzed, and the further research direction of p53 protein kinetics is put forward.
【作者单位】：四川大学华西公共卫生学院(华西第四医院);
【基金】：国家自然科学基金面上项目(NO.81372945)
【分类号】：R3411

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