细菌的噬菌体感染耐受机制研究进展

发布时间：2018-05-05 06:05

本文选题：细菌 + 噬菌体　；参考：《军事医学》2016年07期

【摘要】：噬菌体是能感染细菌的病毒,在自然界中分布十分广泛。随着发酵工业中的噬菌体污染以及多药耐药菌株的出现,噬菌体越来越受到关注。噬菌体感染细菌包括吸附、注入、复制、组装、释放等环节;细菌在与噬菌体的共进化过程中,针对这些环节产生了不同的抗感染机制。该文围绕抗吸附、超感染排斥、限制修饰系统、CRISPR系统、流产感染、组装感染等细菌的噬菌体感染耐受机制研究进行了简要综述。
[Abstract]:Bacteriophages are viruses that infect bacteria and are widely distributed in nature. With the contamination of bacteriophages in fermentation industry and the emergence of multidrug resistant strains, bacteriophages have attracted more and more attention. Bacteriophage infection bacteria include adsorption, injection, replication, assembly, release, etc. In the process of co-evolution with bacteriophage, different anti-infection mechanisms are produced. In this paper, the mechanisms of bacteriophage infection tolerance of bacteria such as anti-adsorption, superinfection rejection, restriction modification system, abortion infection, assembly infection and so on are briefly reviewed.
【作者单位】：安徽医科大学;军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室;青海省地方病预防控制所;
【基金】：国家自然科学基金面上资助项目(31360034;31470138)
【分类号】：R37

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