有机阴离子转运体研究的最新进展

发布时间：2018-05-11 23:13

本文选题：有机阴离子转运体 + 信号通路　；参考：《药学学报》2016年07期

【摘要】：有机阴离子转运体(organic anion transporter,OAT)亚家族是溶质转运体22(solute carrier 22,SLC22)家族中的重要组成部分,在包括肝脏、肾脏、脑及胎盘等在内的多种组织脏器中表达。因其能够介导许多常见药物(抗生素、抗病毒药、利尿药和非甾体类抗炎药)、毒素以及营养物质在机体内的排泄而受到了广泛的关注。近年来,在Oat1和Oat3基因敲除鼠的代谢组学和微阵列数据以及系统生物学的研究表明,OAT通路在处理肠道微生物代谢和肾脏疾病状态下发挥着非常重要的作用。核受体和其他转录因子会与Ⅰ相和Ⅱ相药物代谢酶结合并调节特定OATs的表达。"远端遥感和信号通路假说"表明,OATs能在许多组织中表达并且转运多种信号分子。一些OATs对于特定的信号分子,如环核苷酸、尿酸和前列腺素等还具有高度的选择性,因此可以有效的介导多种器官、组织及细胞间的信息交流。OATs在正常情况及急慢性病理条件下,在内外源物的转运中起到重要作用。
[Abstract]:The organic anion transporter (anion) subfamily is an important component of the solute transporter 22(solute carrier 22SLC22 family, which is expressed in various tissues and organs including liver, kidney, brain and placenta. Because of its ability to mediate the excretion of many common drugs (antibiotics, antiviral drugs, diuretics and nonsteroidal anti-inflammatory drugs), toxins and nutrients in the body have attracted wide attention. In recent years, studies on metabolomics, microarray data and systems biology of Oat1 and Oat3 knockout mice have shown that the Oat1 pathway plays a very important role in the treatment of intestinal microbial metabolism and renal disease. Nuclear receptors and other transcription factors bind to drug metabolic enzymes in phases I and II and regulate the expression of specific OATs. " The remote sensing and signaling pathway hypothesis suggests that OATs can express and transport multiple signaling molecules in many tissues. Some OATs are highly selective for specific signaling molecules such as cyclic nucleotides, uric acid and prostaglandins, so they can effectively mediate a variety of organs. Information exchange between tissues and cells. OATs plays an important role in the transport of exogenous substances in normal and acute and chronic pathological conditions.
【作者单位】：大连医科大学药学院;
【基金】：国家自然科学基金资助项目(81273580,81473280)
【分类号】：R363

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