TRIP-Br2的生物学作用

发布时间：2018-05-12 21:36

本文选题：TRIP-Br + 能量代谢　；参考：《上海交通大学学报(医学版)》2017年10期

【摘要】：TRIP-Br2是一种细胞周期调节因子,能与DP-1特异性结合,参与转录因子E2F-1/DP-1介导的转录增殖活动,维持基因组稳定性。在能量代谢方面,TRIP-Br2作用于启动子E2F-1,抑制脂解作用,降低机体能量代谢率。TRIP-Br2过度表达可激活E2F-1/DP-1介导的细胞周期调控,导致基因组稳定性下降,促进肿瘤的发生。同时,高水平的TRIP-Br2可诱导棕色脂肪细胞释放炎症因子和急性期反应蛋白,产生炎症反应和急性相位反应。该文对TRIP-Br2的自身分子结构及其在增殖、代谢、炎症等过程中的生物学作用进行综述。
[Abstract]:TRIP-Br2 is a cell cycle regulator, which can specifically bind to DP-1, participate in transcription proliferation mediated by transcription factor E2F-1/DP-1, and maintain genomic stability. In the aspect of energy metabolism, TRIP-Br2 acts on promoter E2F-1, inhibits lipopolysis, and reduces the rate of energy metabolism. The overexpression of TRIP-Br2 can activate the regulation of cell cycle mediated by E2F-1/DP-1, lead to the decrease of genomic stability and promote the development of tumor. At the same time, high level of TRIP-Br2 can induce brown adipocytes to release inflammatory factors and acute phase reactive proteins, and to produce inflammatory response and acute phase reaction. In this paper, the molecular structure of TRIP-Br2 and its biological role in proliferation, metabolism and inflammation are reviewed.
【作者单位】：上海交通大学附属第一人民医院上海市眼底病重点实验室上海市眼视觉及光医学工程研究中心;
【基金】：国家自然科学基金(81470643)~~
【分类号】：R3416

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