肌细胞特异性microRNAs生物学效应研究进展

发布时间：2018-05-16 16:14

本文选题：肌细胞特异性microRNAs + 生物学效应　；参考：《中国细胞生物学学报》2016年06期

【摘要】：micro RNAs(mi RNAs)是一类含有20~22个核苷酸的非编码单链小分子RNA,发挥转录后水平负调控基因表达和翻译的作用,具有生物学功能多样性,可作为多种疾病诊断和预后重要分子标志。该文介绍了肌细胞特异性mi RNAs,如mi R-1、mi R-133、mi R-145、mi R-206基因等染色体分布、序列、组织表达丰度、主要通路,并对肌细胞特异性mi RNAs在气管平滑肌、血管平滑肌、心肌等细胞中的生物学效应研究进展进行综述。
[Abstract]:Micro RNAs(mi RNas is a class of non-coding single-stranded small RNAs containing 20 ~ 22 nucleotides, which play a role in the negative regulation of gene expression and translation at post-transcriptional level. It has a variety of biological functions and can be used as an important molecular marker for the diagnosis and prognosis of many diseases. The chromosomal distribution, sequence, tissue abundance and main pathway of myocyte specific mi RNAsS, such as myocyte specific mi RNas, such as mi R-133n mi R-133mmi R-145mi R-206, were introduced. The specific myocyte specific mi RNAs was found in trachea smooth muscle, vascular smooth muscle, and so on. Advances in the study of biological effects in cardiac muscle and other cells are reviewed.
【作者单位】：上海中医药大学;
【基金】：国家自然科学基金(批准号:81473760;81574058) 上海市卫生系统优秀青年人才培养计划(批准号:XYQ2013081) 上海市中医药事业发展三年行动计划重大研究项目(批准号:ZY3-CCCX-3-3005)资助的课题~~
【分类号】：R3416

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