颊针疗法在类风湿关节炎家兔模型镇痛效应中的特点研究

发布时间：2018-05-19 14:23

本文选题：关节炎 + 类风湿　；参考：《中国全科医学》2017年33期

【摘要】：目的观察颊针疗法在类风湿关节炎兔模型镇痛效应中的特点,为颊针临床留针时间、疗程的制定提供理论依据。方法 2014年1—9月将筛选合格的40只清洁级大耳白兔随机分成正常组、模型组、体针组、颊针组,每组10只。模型组、体针组、颊针组制备类风湿关节炎兔模型,正常组不予处理。实验第27天开始正常组和模型组均予以体针组、颊针组相同方法固定30 min;体针组选双侧后肢膝眼和足三里针刺,留针30 min,1次/d;颊针组选颊针膝穴针刺,留针20 min,1次/d;4组均连续治疗10次,分别在治疗第1、4、7、10次针刺时测定针刺0、5、15、30、60、120、240 min各时间点痛阈值。结果第1、4、7、10次针刺方法和时间在痛阈值上存在交互作用(P0.05),时间在痛阈值上主效应显著(P0.05),针刺方法在痛阈值上主效应不显著(P0.05)。正常组和模型组的痛阈值无时间效应(P0.05),体针组和颊针组的痛阈值有时间效应(P0.01)。颊针组时间在痛阈值上主效应显著(F=15.473,P0.001),颊针组时间与针刺次数在痛阈值上不存在交互作用(F=0.973,P=0.486)。颊针组第1次针刺时镇痛效应量效曲线与第7次针刺时比较,差异有统计学意义(t=-3.227,P=0.012);颊针组第7次针刺时镇痛效应量效曲线与第10次针刺时比较,差异无统计学意义(t=0.463,P=0.656)。结论颊针疗法的镇痛效应具有明显的时间变化曲线,且具有起效快、上升快、下降亦快的特点。
[Abstract]:Objective to observe the analgesic effect of buccal acupuncture therapy in rheumatoid arthritis rabbit model and to provide theoretical basis for the clinical retention time and course of buccal acupuncture. Methods from January to September 2014, 40 clean grade white rabbits were randomly divided into normal group, model group, body acupuncture group and buccal acupuncture group with 10 rabbits in each group. The model group, body acupuncture group and buccal acupuncture group were used to prepare rabbit model of rheumatoid arthritis. From the 27th day of the experiment, the normal group and the model group were given body acupuncture group, buccal acupuncture group was fixed with the same method for 30 mins, the body acupuncture group was treated with bilateral posterior limb knee eye and Zusanli acupuncture, and the acupuncture was kept for 30 mins, and the buccal needle group was treated with buccal acupuncture at knee point. All the 4 groups were treated continuously for 10 times at 20 mins / d, and the pain threshold at each time point of acupuncture was measured at each time point of 0 ~ 5 ~ 1530 ~ 60 ~ 120240 min during the first 4 ~ (th) ~ (th) Acupuncture. Results there was an interaction between acupuncture method and time on the pain threshold, the main effect of time on the pain threshold was significant (P 0.05), but the main effect of acupuncture on the pain threshold was not significant (P 0.05). The pain threshold of normal group and model group had no time effect (P 0.05), but the pain threshold of body acupuncture group and buccal acupuncture group had time effect (P 0.01). In buccal acupuncture group, the main effect on the pain threshold was significant, and there was no interaction between the time of buccal acupuncture group and the times of acupuncture on the pain threshold, and there was no interaction between the time of buccal acupuncture group and the times of acupuncture on the pain threshold. In buccal acupuncture group, the dose-effect curve of analgesic effect at the first acupuncture was significantly different from that at the 7th acupuncture, and there was no significant difference between the buccal acupuncture group and the 10th acupuncture group. Conclusion the analgesic effect of buccal acupuncture has obvious time-varying curve, and it has the characteristics of quick onset, fast rising and fast decreasing.
【作者单位】：甘肃中医药大学针灸推拿学院;天水瑞生堂连锁国医馆;
【基金】：国家自然科学基金资助项目(81260559)
【分类号】：R245;R-332

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