薏苡仁多糖不同组分对脾虚水湿不化大鼠模型免疫功能的影响
发布时间:2018-05-19 21:11
本文选题:薏苡仁多糖组分 + 脾虚水湿不化 ; 参考:《中华中医药杂志》2017年03期
【摘要】:目的:研究薏苡仁多糖不同组分对脾虚水湿不化大鼠模型免疫功能的影响。方法:采用高脂低蛋白加力竭游泳法复制脾虚水湿不化大鼠模型,检测模型大鼠体质量、血清蛋白、胸腺指数、脾脏指数、血清IFN-γ、IL-2、IL-4、IgG、IgA、C3水平。结果:给药干预后,与模型对照组比较,粗多糖组和多糖组分Ⅰ组大鼠体质量,血清蛋白,胸腺指数,脾脏指数,血清IFN-γ、IL-2、IgG、IgA、C3含量显著升高(P0.05,P0.01),IL-4含量显著降低(P0.05)。结论:薏苡仁多糖不同组分能改善脾虚水湿不化大鼠免疫功能,其中多糖组分Ⅰ作用显著。其机制可能与恢复Th1/Th2平衡,提高免疫球蛋白等的水平有关。
[Abstract]:Aim: to study the effect of different components of Coix seed polysaccharides on immune function in rats with spleen deficiency and dampness. Methods: the rat model of spleen deficiency without dampness was made by using high fat and low protein and exhaustive swimming. The body weight, serum protein, thymus index, spleen index and serum IFN- 纬 -2IL-2IL-4IL-4 / IgGG _ 4 IgA _ 3 level were detected in the model rats. Results: compared with the model control group, the body weight, serum protein, thymus index, spleen index, serum IFN- 纬 -IL-2IgGG, IgAC _ 3 content of crude polysaccharide group and polysaccharide component 鈪,
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