细胞焦亡效应机制及相关疾病研究进展

发布时间：2018-05-24 03:02

  本文选题：细胞焦亡 + GSDMD　； 参考：《医学研究生学报》2017年06期

【摘要】：细胞焦亡是新近发现的一种程序性细胞死亡形式,与感染性疾病、自发炎症性疾病和自身免疫性疾病休戚相关,Gasdermin-D(GSDMD)是细胞焦亡的效应分子。炎性半胱天冬酶(caspases)通过裂解GSDMD,打破其结构自抑制,激活GSDMD的打孔活性。GSDMD的活性形式GSDMD-N端结构域在细胞膜上聚合形成一个中空的环状低聚物,形成孔道。细胞焦亡与程序性细胞坏死相似,两者均能在细胞膜上形成孔道。文章就细胞焦亡的研究进展、GSDMD参与细胞焦亡的分子机制、细胞焦亡与程序性细胞死亡的辨别及与细胞焦亡相关的疾病进行综述。
[Abstract]:Apoptosis is a newly discovered programmed cell death form. It is closely related to infectious diseases, spontaneous inflammatory diseases and autoimmune diseases. Gasdermin-D GSDMDD) is the effector molecule of cellular pyrolysis. Inflammatory cysteine aspergase (caspaseses) cleavage GSDMDs, break down its structural self-inhibition, and activate the perforation activity of GSDMD. The active form of GSDMD-N terminal domain of GSDMD polymerizes on the cell membrane to form a hollow ring oligomer, forming a pore channel. Pyrolysis is similar to programmed cell necrosis, both of which can form pores on the cell membrane. In this paper, the molecular mechanism of GSDMD involved in cell pyrolysis, the discrimination between cellular pyrolysis and programmed cell death, and the diseases related to cell pyrolysis are reviewed.
【作者单位】： 广东医科大学;广东医科大学附属医院心血管内科;
【基金】：国家自然科学基金(81270262)
【分类号】：R363
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本文编号：1927428