外泌体对缺血再灌注器官损伤的保护作用

发布时间：2018-05-27 22:09

本文选题：外泌体 + 缺血再灌注　；参考：《中国修复重建外科杂志》2017年06期

【摘要】：目的总结外泌体对缺血再灌注器官损伤的保护作用,为其治疗提供新思路。方法广泛查阅近年国内外与外泌体治疗缺血再灌注损伤相关的文献,分析总结其作用机制。结果外泌体体积小,存在于血液、脑脊液、尿液等细胞外液中,能够穿透血脑屏障,可通过多种分子机制对心脏、脑等器官的缺血再灌注损伤起到保护作用,并且无肝、肾副作用。结论外泌体治疗可能成为逆转缺血再灌注器官损伤的新方法,了解外泌体对缺血再灌注损伤的保护作用及可能机制具有重要意义。
[Abstract]:Objective to summarize the protective effect of exocrine on ischemia-reperfusion injury and to provide new ideas for its treatment. Methods the literatures related to the treatment of ischemia / reperfusion injury by exocrine were reviewed extensively in recent years, and the mechanism of the action was analyzed and summarized. Results the exocrine was small in the blood, cerebrospinal fluid, urine and other extracellular fluids. It could penetrate the blood-brain barrier and protect the heart, brain and other organs from ischemia-reperfusion injury through a variety of molecular mechanisms, and had no liver. Conclusion Exocrine therapy may be a new method to reverse the injury of ischemia-reperfusion organ. It is of great significance to understand the protective effect of exocrine on ischemia-reperfusion injury and its possible mechanism.
【作者单位】：四川大学华西第二医院儿科出生缺陷与相关妇儿疾病教育部重点实验室;
【基金】：国家自然科学基金资助项目(81330016、81630038、81270724) 国家重点基础研究发展计划项目(973计划)(2013CB967404、2012BAI04B04) 四川省科技计划项目(2014SZ0149、2016TD0002)~~
【分类号】：R363

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