HBZ在人类T淋巴细胞白血病1型病毒HTLV-1致癌中的功能

发布时间：2018-06-04 12:56

本文选题：人类T淋巴细胞白血病型病毒 + 成人T细胞白血病　；参考：《病毒学报》2016年02期

【摘要】：人类T淋巴细胞白血病1型病毒(Human T-cell leukemia virus type 1,HTLV-1)是与人类疾病发生密切相关的逆转录病毒,HTLV-1的感染可引起成人T细胞白血病(Adult T-cell leukemia,ATL)。HBZ(HTLV-1bZIP factor)是由HTLV-1前病毒反义链编码的病毒蛋白。在HTVL-1所编码的病毒基因中,HBZ是唯一一个在所有ATL病人样品中持续、稳定表达的病毒基因。而且,HBZ在HTLV-1诱发肿瘤的过程中发挥着极其重要的作用。近十年来对HBZ结构及其功能的研究成为白血病研究领域的热点。因此,本文就HBZ在HTLV-1致癌机制方面的相关研究成果作一综述。
[Abstract]:Human T lymphocytic leukemia virus type 1 (T-cell leukemia virus type 1) is a viral protein encoded by antisense chain of HTLV-1 previrus (HTLV-1 previrus antisense chain), which is caused by human T cell leukemia virus (HTLV-1) infection, which is closely related to the occurrence of human diseases. It can cause adult T cell leukemia (T cell leukemia) to be induced by human T cell leukemia (Adult T-cell leukemia) ATLN. HBZG (HTLV-1bZIP factor) is a viral protein encoded by antisense chain of HTLV-1 previrus. Among the viral genes encoded by HTVL-1, HBZ is the only one that can be expressed stably in all ATL patient samples. HBZ plays a very important role in the process of HTLV-1 inducing tumor. In recent ten years, the research on the structure and function of HBZ has become a hot topic in the field of leukemia. Therefore, this article reviews the research results of HBZ in HTLV-1 carcinogenesis.
【作者单位】：浙江师范大学化学与生命科学学院;华侨大学生物医学学院;
【基金】：国家自然科学基金面上项目(No.31470262) 浙江省科技厅公益技术应用研究计划项目(No.2015C33149) 浙江省"重中之重"学科"生物学"2014年度开放基金项目(KFJJ2014003)
【分类号】：R373

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