脂肪干细胞成脂分化的分子机制和信号通路

发布时间：2018-06-07 05:59

本文选题：干细胞 + 成脂分化　；参考：《中国组织工程研究》2017年01期

【摘要】：背景:对脂肪干细胞成脂分化的研究不仅可探索肥胖的过程和机制,还可构建组织工程脂肪,为软组织缺损的重建提供新的思路。目的:总结脂肪干细胞成脂分化的过程、分子机制和信号通路,讨论miRNA对脂肪干细胞成脂分化的影响及脂肪干细胞成脂和成骨分化的关系。方法:应用计算机检索Pub Med数据库、Sino Med数据库中有关脂肪干细胞分化的文献,检索词为"adipose stem cell,adipose-derived stem cell,adipose-derived mesenchymal stem cell,differentiation;脂肪干细胞,分化",最终选取代表性文献共27篇。结果与结论:在脂肪干细胞成脂分化过程中,PPARγ/MAPK、PI3K/Akt、Wnt/β-Catenin、cA MP、Notch等信号通路发挥了关键作用,但其相关基因和蛋白、信号通路和分子机制仍不完全清楚。miR NA对脂肪干细胞的成脂分化有重要影响,miR-24、miR-148a、miR-302等可促进脂肪干细胞的成脂分化,miR-22、miR-27等可抑制脂肪干细胞的成脂分化。脂肪干细胞的成骨和成脂分化关系密切,部分生长因子和激素在促进脂肪干细胞成脂分化的同时抑制其成骨分化,部分作用则相反。综合利用各种细胞因子和支架模拟体内微环境,促进脂肪干细胞的增殖和成脂分化,构建组织工程脂肪,是未来的研究方向。
[Abstract]:Background: the study of adipogenic differentiation of adipose stem cells can not only explore the process and mechanism of obesity but also construct tissue engineered fat and provide a new idea for reconstruction of soft tissue defects. Aim: to summarize the process of adipogenic differentiation, molecular mechanism and signal pathway of adipose stem cells, and discuss the effect of miRNA on adipose stem cell adipogenic differentiation and the relationship between adipose stem cell adipogenesis and osteogenic differentiation. Methods: the literatures on adipose stem cell differentiation in Pub Med database Sino Med were searched by computer. The key words were "adipose stem cell adipose-derived stem adipose-derived mesenchymal stem cell differentiation; adipo-stem cell differentiation, differentiation". Results & conclusion: PPAR 纬 -MAPK / PI3K / 尾 -Catenin C A MPN Notch signaling pathway plays a key role in adipogenic differentiation of adipose stem cells, but its related genes and proteins play a key role in adipose stem cell adipogenic differentiation. The signaling pathway and molecular mechanism are still unclear. MIRNA plays an important role in adipogenic differentiation of adipose stem cells. MiR-24 miR-148amiR-302 can promote adipogenic differentiation. MiR-22miR-27 can inhibit adipogenic differentiation of adipose stem cells. The osteogenesis and adipogenic differentiation of adipose stem cells were closely related. Some growth factors and hormones inhibited adipose stem cells osteogenic differentiation while promoting adipose stem cell adipogenic differentiation. Comprehensive use of various cytokines and scaffolds to simulate the microenvironment, promote the proliferation and adipogenic differentiation of adipose stem cells, and construct tissue engineered fat, is the future research direction.
【作者单位】：解放军总医院整形修复科;美国德克萨斯大学MD安德森肿瘤中心整形外科;解放军总医院皮肤科;
【分类号】：R329.2

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