造血干细胞生理调控及其分子基础研究进展

发布时间：2018-06-10 06:14

本文选题：造血干细胞 + 自我更新　；参考：《生理学报》2016年04期

【摘要】：造血干细胞(hematopoietic stem cell,HSC)是发现最早、研究较多、在临床中广泛应用并一直起着范式作用的一类重要的成体组织干细胞。HSC研究被认为是整个干细胞生物学和再生医学的主要奠基学科之一。HSC具有自我更新、多向分化、静息维持、凋亡控制和运动迁移这五大特性。这些特性既相互影响,又互相制约,共同组建成HSC功能的生理调控网络。本文将围绕构成HSC生物学的这五个主要方面在生理条件下的相关研究机制进行综述,旨在通过对HSC功能调控的认识为其它类型的成体干细胞研究及应用提供引领和示范作用,从而为整个干细胞与再生医学的发展奠定坚实的基础。
[Abstract]:Hematopoietic stem cell is the first to be discovered, and there are many researches on it. A class of important adult tissue stem cells. HSC, which has been widely used in clinical practice and has been playing a role in normal form, is considered to be one of the main foundational disciplines of stem cell biology and regenerative medicine. HSC has self-renewal, multi-differentiation, and resting maintenance. Apoptosis control and motor migration are five characteristics. These characteristics influence and restrict each other and form the physiological regulation network of HSC function. In this paper, we will review the relevant research mechanisms of these five main aspects of HSC biology under physiological conditions, in order to provide guidance and demonstration for other types of adult stem cell research and application through the understanding of HSC function regulation. Thus lay a solid foundation for the development of stem cells and regenerative medicine.
【作者单位】：中国医学科学院北京协和医学院血液病医院血液学研究所实验血液学国家重点实验室;中国医学科学院干细胞医学中心;北京协和医学院干细胞与再生医学系;肿瘤医学协同创新中心;
【基金】：supported by the Major Research Plan from the Ministry of Science and Technology of China(No.2016YFA0100600,2015CB964400,2011CB964800,2013CB966902) the National Natural Science Foundation of China(No.81421002,81430004,81330015,91519315)
【分类号】：R329.2

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