自噬与Nrf2信号通路之间联系的研究进展

发布时间：2018-06-22 07:01

本文选题：自噬 + Nrf　；参考：《中国细胞生物学学报》2016年12期

【摘要】：自噬是人体内常见且重要的生理现象之一,对于维持细胞的稳定及代谢需要具有关键意义。核因子E2相关因子(nuclear factor erythroid-derived factor 2-related factor,Nrf2)是调控细胞对抗外来异物和氧化损伤的关键转录因子,Nrf2信号通路在抗肿瘤、抗应激等方面发挥着广泛的细胞保护功能。随着研究进展,发现自噬与Nrf2信号通路间存在着广泛的相互作用机制。抑制自噬会导致p62积累,进而结合Keap1(Kelch-like ECH-associated protein 1)而激活Nrf2信号通路;同时也有研究发现,磷脂酰肌醇-3-激酶/蛋白激酶B(phosphatidyl inositol 3-kinase/protein kinase B,PI3K/Akt)等自噬和Nrf2的共同调节通路、活性氧(reactive oxidative species,ROS)等因素也参与自噬与Nrf2之间的相互调控。该文将以近期关于Nrf2信号通路与自噬之间关系研究进展作一综述,希望为临床疾病治疗提供新的视角。
[Abstract]:Autophagy is one of the common and important physiological phenomena in human body. Nuclear factor E2 (nuclear factor erythroid-derived factor 2-related factor-Nrf2) is a key transcriptional factor that regulates cell resistance to foreign bodies and oxidative damage. Nrf2 signaling pathway plays a wide range of cytoprotective functions in anti-tumor and anti-stress aspects. With the development of research, it is found that there are extensive interaction mechanisms between autophagy and Nrf2 signaling pathway. Inhibition of autophagy leads to p62 accumulation, which in turn activates the Nrf2 signaling pathway combined with Keap1 (Kelch-like ECH-associated protein 1). At the same time, it has also been found that autophagy and Nrf2 co-regulate pathways such as phosphatidylinositol -3-kinase / protein kinase B (phosphatidyl inositol 3-kinase/protein kinase PI3K / Akt. Reactive oxygen species (reactive oxidative) and other factors are also involved in the interaction between autophagy and NRF 2. This article reviews the recent progress in the study of the relationship between Nrf2 signaling pathway and autophagy in order to provide a new perspective for the treatment of clinical diseases.
【作者单位】：中国医科大学七年制第二临床学院;中国医科大学公共卫生学院;
【基金】：辽宁省教育厅基金(批准号:L2010705)资助的课题~~
【分类号】：R363

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