采用单边可调节外固定架制作兔股骨非感染性骨折不愈合模型

发布时间：2018-06-26 22:46

本文选题：股骨 + 骨折　；参考：《新医学》2016年07期

【摘要】：目的探讨采用单边可调节外固定器制作兔股骨非感染性骨折不愈合模型的可行性。方法将72只新西兰大白兔随机分为15 mm缺损组、10 mm骨蜡缺损组及10 mm缺损组各24只,均行左侧股骨截骨,以单边可调节外固定架为固定装置制成骨缺损模型。15 mm缺损组骨折断端间隙为15 mm,不用骨蜡封堵;10 mm骨蜡缺损组骨折断端间隙为10 mm,用骨蜡封堵髓腔;10 mm缺损组骨折断端间隙为10 mm,不用骨蜡封堵。术后通过进行大体观察、X线检查及病理组织学检查,观察3组股骨对位情况和截骨端的愈合情况,比较各组骨折不愈合率(制模成功率)。结果术后8周,15 mm缺损组有23只大白兔、10 mm骨蜡缺损组有22只大白兔、10 mm缺损组有23只大白兔纳入统计。15 mm缺损组22只(95.7%)、10 mm骨蜡缺损组20只(90.9%)、10 mm缺损组10只(43.5%)的X线检查结果符合骨折不愈合表现。3组骨折不愈合率总体比较的χ2=21.17,P0.001。与10 mm缺损组比较,15 mm缺损组及10 mm骨蜡缺损组的骨折不愈合率均较高(P均0.001)。15 mm缺损组与10 mm骨蜡缺损组间骨折不愈合率比较差异无统计学意义(P=0.608)。结论采用单边可调节外固定架制作骨折断端间隙为15 mm以及骨折断端间隙为10 mm且用骨蜡封堵髓腔的2种兔股骨非感染性骨折不愈合模型是可行的。
[Abstract]:Objective to investigate the feasibility of using unilateral adjustable external fixator to establish nonunion model of noninfectious femoral fractures in rabbits. Methods Seventy-two New Zealand white rabbits were randomly divided into 15 mm defect group (n = 24) and 10 mm defect group (n = 24). Using unilateral adjustable external fixator as fixator to make bone defect model .15mm defect group fracture end gap is 15 mm, without bone wax sealing 10 mm bone wax defect group fracture broken end gap is 10 mm, bone wax is used to block bone marrow cavity 10 mm defect group The fracture end space is 10 mm and no bone wax is needed. By means of gross observation X-ray examination and histopathological examination, the position of femur and the healing of osteotomy in three groups were observed, and the nonunion rate of fracture (success rate of model making) in each group was compared. Results Twenty-three rabbits with 10 mm bone wax defect in the 15 mm defect group (8 weeks after operation) were included in the 10 mm bone wax defect group. 22 (95.7%) 10 mm bone wax defect group (20 (90.9%) and 10 mm bone wax defect group (10 (43.5%) were included in the 15 mm defect group (22 (95.7%) and the 10 (10 mm) bone wax defect group (20 (90.9%) were included in the 10 mm bone wax defect group (10 (43.5%). The results of X-ray examination were consistent with the manifestations of fracture nonunion. 3. The overall rate of nonunion of fracture in group 3 was compared with that of 蠂 2, 21. 17, P 0. 001. There was no significant difference in the rate of nonunion between the 15 mm defect group and the 10 mm bone wax defect group (P 0.001). There was no significant difference between the 10 mm bone wax defect group and the 10 mm bone wax defect group (P < 0. 608). Conclusion it is feasible to use unilateral adjustable external fixator to make two kinds of nonunion models of femoral non-infectious fracture in which the fracture end gap is 15 mm and the fracture end gap is 10 mm and the bone wax is used to block the medullary cavity.
【作者单位】：承德医学院附属医院创伤小儿骨科;
【基金】：河北省医学科学研究课题(ZL20140067)
【分类号】：R683;R-332

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