适度运动对人体肠道菌群结构的影响

发布时间：2018-06-28 08:50

本文选题：肠道菌群 + 运动　；参考：《第三军医大学学报》2017年18期

【摘要】：目的适度运动有益于身心健康。本研究从肠道菌群结构的角度来探讨运动对人体健康的影响。方法招募运动组和少动组志愿者人群,利用16S r DNA高通量测序技术分析志愿者肠道菌群结构。结果高通量测序共获得61 888个OTUs,其中已注释的OTUs有61 149个。PCo A分析显示,运动组和少动组之间肠道菌群结构存在显著差异。运动组中毛螺菌科(Lachnospiraceae)和拟杆菌科(Bacteroidaceae)的丰度显著高于少动组(P=2.5627×10~(-7),P=0.000 178 4),普雷沃氏菌科(Prevotellaceae)和韦荣氏球菌科(Veillonellaceae)的丰度显著低于少动组(P=0.000 003 46,P=0.000017 41)。有3株可培养的菌株在运动组中丰度显著增加,分别为瘤胃球菌属的Ruminococcus_sp.5_1_39BFAA,双歧杆菌属的Bifidobacterium_adolescentis以及丁酸产盐菌属的Anaerostipes_hadrus。在运动组中显著增加的肠道菌,如拟杆菌科,双歧杆菌属的Bifidobacterium_adolescentis以及Anaerostipes_hadrus,能够代谢产生丰富的SCFAs,对肠粘膜免疫系统动态平衡的维持具有重要意义。结论运动可能通过肠道菌群结构的改变及其与肠黏膜系统的相互作用对人体产生积极影响。
[Abstract]:Objective To study the effects of exercise on human health by using the method of 16S r DNA high flux sequencing . The results showed that there was a significant difference in intestinal flora structure between exercise group and oligodynamic group ( P = 2.5627 脳 10 ~ ( -7 ) , P = 0.000 178 4 ) , Prevotellaceae and Veillonellaceae were significantly lower than those in the group of oligodynamic group ( P = 0.000 003 46 , P = 0.000017 41 ) . The results showed that there were significant changes in the intestinal flora structure and the interaction between the intestinal mucosal immune system and the intestinal mucosal system . Conclusion The changes of intestinal flora structure and its interaction with the intestinal mucosal system may have a positive effect on the human body .
【作者单位】：第三军医大学新桥医院检验科;第三军医大学微生物教研室生物信息中心;
【基金】：国家自然科学基金面上项目(31571352)~~
【分类号】：R333.3

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