三磷酸腺苷结合盒转运子E1功能及其在疾病中作用的研究进展

发布时间：2018-06-30 00:49

本文选题：三磷酸腺苷结合盒转运子E + 细胞增殖　；参考：《山东医药》2017年12期

【摘要】：三磷酸腺苷结合盒转运子E1(ABCE1)作为一种高度保守的转运蛋白,在生物体的多种细胞活动中发挥重要作用。ABCE1特异结合并抑制核糖核酸酶L活性,增强人类免疫缺陷病毒的复制能力;抑制与细胞增殖相关的2-5A/RNase、细胞质L通路;通过影响蛋白质翻译过程的起始、终止、核糖体循环影响真核生物蛋白质的合成;穿梭往返于细胞核质之间,可能涉及转录调控。将ABCE1的miRNAs或siRNA转入耐药肿瘤细胞中抑制其表达,可能提高化疗药物的敏感性,保证肿瘤化疗的可行性及可持续性,为逆转肿瘤耐药提供新的方法。ABCE1表达增高或降低均可降低活性氧的活性,因此,ABCE1亦可能成为治疗氧化应激相关疾病的新的靶基因。
[Abstract]:Adenosine triphosphate binding cassette transporter E1 (ABCE1), as a highly conserved transporter, plays an important role in many cellular activities. ABCE1 specifically binds and inhibits ribonuclease L activity and enhances the replication ability of human immunodeficiency virus. Inhibition of 2-5A / R Nase, cytoplasmic L pathway associated with cell proliferation; ribosome cycle affects the synthesis of eukaryotic proteins by affecting the initiation and termination of protein translation; shuttling between nucleus and cytoplasm, which may involve transcriptional regulation. Transfection of miRNAs or siRNA of ABCE1 into drug-resistant tumor cells may increase the sensitivity of chemotherapeutic agents and ensure the feasibility and sustainability of tumor chemotherapy. In order to reverse tumor drug resistance, the increased or decreased expression of ABCE1 can decrease the activity of reactive oxygen species, so ABCE1 may also become a new target gene for the treatment of oxidative stress-related diseases.
【作者单位】：河北大学医学院;
【基金】：国家自然科学基金青年基金资助项目(81502477) 河北省自然科学基金资助项目(H2015201119)
【分类号】：R363

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