连翘提取物对酵母和脂多糖所致大鼠发热模型的影响研究

发布时间：2018-07-03 16:33

本文选题：连翘提取物 + 解热　；参考：《辽宁中医杂志》2017年02期

【摘要】：目的:对比观察连翘提取物的解热作用,探讨连翘提取物研究中适用的发热模型及推测可能的作用机制。方法:建立酵母(2 g/kg)、脂多糖(LPS)(20μg/kg)致大鼠发热模型,分别测量大鼠的肛温,考察造模后灌胃给药10m L/kg生理盐水、0.2 g/kg阿司匹林、1.25,2.5,5 g/kg连翘提取物后不同时间内大鼠的体温变化。结果:酵母和LPS致热模型制作成功,1.25,2.5 g/kg连翘提取物对发热模型动物的体温影响较小,5 g/kg连翘提取物和阿司匹林可减缓发热模型动物的体温升高趋势,对LPS致热模型的解热作用更显著。结论:连翘提取物对酵母和LPS致热模型有解热作用,对LPS致热模型的解热作用较酵母致热模型更显著,推测其可能是通过抑制PGE2的合成和释放来发挥解热作用。
[Abstract]:Objective: to observe the antipyretic effect of Forsythia suspensa extract, and to explore the suitable febrile model and its possible mechanism in the study of Forsythia suspensa extract. Methods: the rat model of fever induced by yeast (2 g/kg) and lipopolysaccharide (20 渭 g/kg) was established. The anus temperature of rats was measured, and the changes of body temperature of rats after 10 mL / kg normal saline 0.2 g/kg aspirin 1.25 g/kg 2.55 g/kg extract were observed. Results: yeast and LPS-induced febrile model were successfully made with the extract of Forsythia Forsythia Forsythia Forsythiae for 1. 25 g/kg. The antipyretic effect of LPS was more obvious. Conclusion: Forsythia suspensa extract has antipyretic effect on yeast and lipopolysaccharide (LPS) model. The antipyretic effect of Forsythia suspensa extract is more obvious than that of yeast heat model. It is supposed that the antipyretic effect of Forsythia suspensa extract is by inhibiting the synthesis and release of PGE2.
【作者单位】：成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地;
【基金】：国家自然科学基金面上项目(81373943,81573583) 四川省杰出青年基金(2013JQ0018) 四川省科技厅省青年科技创新研究团队专项计划项目——中药药理四川省青年科技创新研究团队(2015TD0028,2016TD0006,2017TD0001) 成都中医药大学科技发展基金(ZRYB201425)
【分类号】：R285.5;R-332

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