小建中汤配伍不同糖类方对胃溃疡模型小鼠预防的比较研究

发布时间：2018-07-07 10:11

本文选题：小建中汤 + 胃溃疡　；参考：《山东中医药大学学报》2016年06期

【摘要】：目的:研究小建中汤配伍不同糖类方对胃溃疡模型小鼠影响的差异及机制。方法 :根据灌胃无水乙醇法建立小鼠胃溃疡模型,给模型小鼠连续灌药7 d后眼球采血检测血清SOD、MDA含量;采血后即处死小鼠,取全胃剖开测定溃疡指数,进行肉眼胃黏膜形态学观察,并行HE染色,显微镜观察胃组织病理学变化。结果:小建中汤饴糖组、小建中汤葡萄糖组能明显降低胃溃疡模型小鼠的溃疡指数,降低溃疡模型小鼠血清中MDA含量,提高SOD含量,与模型组比较存在显著性差异,有统计学意义(P0.05);小建中汤白砂糖组、小建中汤乳糖组与模型组比较无显著性差异。结论:小建中汤饴糖组、小建中汤葡萄糖组对无水乙醇法致小鼠胃溃疡具有一定的预防和保护作用,其机制可能与其抑制体内自由基生成、提高氧自由基清除系统活性等有关。
[Abstract]:Objective: to study the effect and mechanism of Xiaojianzhong decoction (XJD) combined with different carbohydrate prescriptions on gastric ulcer model mice. Methods: the gastric ulcer model of mice was established according to the method of gastric anhydrous ethanol. After 7 days of continuous administration of drugs, the serum levels of SOD MDA were measured in the eyeball of the model mice, and the mice were killed immediately after the blood collection, and the ulcer index was determined by total gastric dissection. The pathological changes of gastric mucosa were observed by microscope and HE staining. Results: Xiaojianzhong Tang caramel group and Xiaojianzhong decoction glucose group could significantly reduce the ulcer index, decrease the MDA content and increase the SOD content in the serum of the gastric ulcer model mice, and there was significant difference between the two groups. There was statistical significance (P0.05); there was no significant difference between the small Jianzhong decoction white sugar group and the lactose group and the model group. Conclusion: Xiaojianzhong Tang caramel group and Xiaojianzhong decoction glucose group have some preventive and protective effects on gastric ulcer induced by anhydrous ethanol in mice. The mechanism may be related to the inhibition of free radical formation in vivo and the enhancement of oxygen free radical scavenging system activity.
【作者单位】：山东中医药大学;
【基金】：山东省自然科学基金项目(编号:Z2010HQ028) 大学生研究训练计划(SRT)(编号:2015027)
【分类号】：R285.5;R-332

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