人Ruvbl1蛋白生物信息分析

发布时间：2018-07-25 12:34

【摘要】：采用生物信息学预测对人AAA+(ATPases associated with diverse cellular Activities)ATP酶家族成员Ruvbl1蛋白质的理化性质、蛋白质同源性、跨膜区域、核定位序列及信号肽、亲/疏水性,蛋白质高级结构、蛋白质间相互作用、GO注释进行预测分析。人Ruvbl1蛋白有456个氨基酸,等电点为6.02,有核定位序列,无信号肽,蛋白质具亲水性且高度保守;二级结构存在21个α螺旋和10个β折叠,相互作用蛋白及GO注释提示其主要在细胞核中发挥功能。人Ruvbl1蛋白是DNA解螺旋的关键酶,通过解螺旋DNA为基因的同源重组以及DNA损伤修复提供结构基础。
[Abstract]:Bioinformatics was used to predict the physicochemical properties, protein homology, transmembrane region, nuclear localization sequence, signal peptide, hydrophilic / hydrophobic, advanced protein structure of Ruvbl1 members of human AAA (ATPases associated with diverse cellular Activities) ATP enzyme family. Protein interactions were predicted by go annotation. Human Ruvbl1 protein has 456 amino acids, isoelectric point 6.02, nuclear localization sequence, no signal peptide, the protein is hydrophilic and highly conserved, the secondary structure has 21 伪 helix and 10 尾 folds. Interaction proteins and go annotations indicate that they play a major role in the nucleus. Human Ruvbl1 protein is the key enzyme of DNA unhelix, which provides structural basis for homologous recombination of gene and repair of DNA damage.
【作者单位】：天津医科大学肿瘤医院国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心;
【基金】：国家自然科学基金资助项目(81301711)资助
【分类号】：R3416

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