人类环境病原真菌——新生隐球菌的社会行为

发布时间：2018-08-09 20:13

【摘要】：人类病原真菌代表了病原微生物一个重要类群,主要感染免疫缺陷、受损和受抑制的患者,导致很高的死亡率。绝大多数的人类病原真菌属于环境病原微生物,它们与人类宿主并无长期共同进化史以及紧密的共生关系,这类真菌被称为环境病原真菌。新生隐球菌作为环境病原真菌的模式种,每年导致约60万人死亡。与其他环境病原真菌相似,该菌的致病能力并不由宿主因素驱动,而是衍生于其对于生境压力出色的适应性策略。近几年来的研究表明,群体或社会行为可能作为一个关键环境适应策略,广泛参与新生隐球菌的感染、耐药以及有性生殖过程。本文以新生隐球菌为例,针对生物被膜以及生物被膜样群落,总结其中的群体或社会调控方式,并对其研究前景和临床应用提出了一些思考。
[Abstract]:Human pathogenic fungi represent an important group of pathogenic microorganisms, which mainly infect immunodeficient, damaged and suppressed patients, resulting in a high mortality rate. Most of the human pathogenic fungi belong to environmental pathogenic microorganisms. They have no long-term common evolutionary history and close symbiotic relationship with human hosts. These fungi are called environmental pathogenic fungi. Cryptococcus neoformans (Cryptococcus neoformans), a model species of environmental fungi, kills about 600000 people every year. Similar to other environmental pathogenic fungi, its pathogenicity is not driven by host factors, but derived from its excellent adaptability to habitat stress. In recent years studies have shown that colony or social behavior may be a key environmental adaptation strategy widely involved in Cryptococcus neoformans infection drug resistance and sexual reproduction process. In this paper, taking Cryptococcus neoformans as an example, we summarize the population or social regulation methods for biofilm and biofilm-like communities, and put forward some thoughts on its research prospect and clinical application.
【作者单位】：中国科学院微生物研究所真菌学国家重点实验室;中国科学院大学;
【基金】：国家自然科学基金(Nos.31570138,31501008) 中国科学院前沿科学重点研究项目(No.QYZDB-SSW-SSMC040)资助~~
【分类号】：R379.5

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