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复方星夏汤对痰湿型多囊卵巢综合征模型小鼠肿瘤坏死因子-α、白细胞介素-6的影响

发布时间:2018-08-14 10:53
【摘要】:目的:观察复方星夏汤对痰湿型多囊卵巢综合征(PCOS)模型小鼠肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的影响,初步探究复方星夏汤治疗痰湿型PCOS的作用机理。方法:采用硫酸脱氢表雄酮联合链脲佐菌素及高脂高糖饲料法建立痰湿型PCOS小鼠模型。选取23日龄ICR雌性小鼠72只,随机分为4组:空白对照组、模型组、复方星夏汤组、达英-35组,每组18只。比较各组小鼠体质量变化、E2、T、LH、FSH、FPG、FINS、TNF-α、IL-6水平,并计算LH/FSH比值、HOMA-IR指数,对所取卵巢进行病理切片,在光学显微镜下观察其组织形态学变化。结果:复方星夏汤组、达英-35组均可以使痰湿型PCOS小鼠体质量,LH、LH/FSH比值,FPG、FINS、HOMA-IR指数,TNF-α水平下降,保持或恢复卵巢正常组织形态结构;其中在降低IL-6水平、HOMA-IR指数方面显著优于达英-35组(P0.01)。结论:复方星夏汤可能通过降低血清中TNF-α、IL-6水平改善胰岛素抵抗(IR),直接或间接调节内分泌激素及生殖轴,促使卵泡发育成熟及排卵,提高生殖能力。
[Abstract]:Objective: to observe the effect of compound Xingxia decoction on the levels of tumor necrosis factor- 伪 (TNF- 伪) and interleukin-6 (IL-6) in (PCOS) model mice with phlegm-dampness type polycystic ovary syndrome (PCOS), and to explore the mechanism of Fufang Xingxia decoction in treating PCOS with phlegm dampness type. Methods: PCOS mice model of phlegm dampness was established by dehydroepiandrosterone sulfate combined with streptozotocin and high fat and high sugar diet. Seventy-two ICR female mice aged 23 days were randomly divided into 4 groups: blank control group, model group, compound Xingxia decoction group, Daying 35 group, 18 rats in each group. The body mass changes of each group were compared. The LH/FSH ratio and HOMA-IR index were calculated. The histological changes of the ovary were observed under optical microscope. Results: both the compound Xingxia decoction group and Da-35 group could decrease the level of TNF- 伪 and maintain or restore the normal structure of ovary in PCOS mice with phlegm-dampness type and the ratio of LHH / FSH to FINSHOMA-IR was significantly higher than that of Dain-35 group in decreasing the level of IL-6 (P0.01). Conclusion: compound Xingxia decoction can improve insulin resistance (IR), directly or indirectly regulate endocrine hormone and reproductive axis, promote follicle development, maturation and ovulation, and improve reproductive ability by reducing serum TNF- 伪 IL-6 level.


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