白色念珠菌生物被膜研究进展

发布时间：2018-08-14 20:08

【摘要】：难治性真菌感染的临床分析发现,病灶感染病原常以生物被膜的形态存在。生物被膜的形成可帮助真菌躲避宿主细胞免疫系统清除和药物的攻击,所造成的持续性感染严重威胁人类健康,因此,认识研究真菌生物被膜及其耐药机理对于防治临床真菌感染有着重大意义。白色念珠菌是一种临床感染常见的条件性致病菌,也是目前真菌生物被膜研究的主要研究模型。白色念珠菌生物被膜主要由多糖、蛋白质和DNA构成,其形成由微生物间的群体感应调控,并受到环境中营养成分及其附着物表面性质影响。研究发现,胞外基质的屏障作用、耐药基因的表达等机制与生物被膜耐药性的产生密切相关。本文就白色念珠菌生物被膜的形成过程、结构组成、形成的影响因素、现有研究模型、耐药机制和治疗策略等几个方面介绍近年来的研究进展。
[Abstract]:The clinical analysis of refractory fungal infection showed that the pathogen of focal infection often existed in the form of biofilm. The formation of biofilm can help fungi escape from host cellular immune system clearance and drug attacks, resulting in persistent infections that pose a serious threat to human health. The study of fungal biofilm and its drug resistance mechanism is of great significance in the prevention and treatment of fungal infection. Candida albicans is a common opportunistic pathogen in clinical infection, and it is also the main research model of fungal biofilm. The biofilm of Candida albicans is mainly composed of polysaccharides, proteins and DNA. The formation of Candida albicans biofilm is regulated by the population induction between microbes and is affected by the nutrient composition and the surface properties of its appendages in the environment. It was found that the barrier function of extracellular matrix and the expression of drug resistance genes were closely related to the production of biofilm resistance. In this paper, the recent progress in the research of Candida albicans biofilm formation process, structure composition, influencing factors, existing research models, drug resistance mechanism and treatment strategies were reviewed.
【作者单位】：中国科学院过程工程研究所生化工程国家重点实验室;中国科学院大学;
【基金】：国家自然科学基金(31670809)~~
【分类号】：R379.4

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