机体胆汁酸肠-肝轴的研究进展
发布时间：2018-08-28 10:12
【摘要】：机体肠道与肝脏间的交互作用形成肠-肝轴,后者的紊乱是肝脏疾病发生的重要原因,而良好的肠道稳态和肝脏的保护对维持机体内环境的稳定起着重要作用。胆汁酸(胆盐)作为肠-肝轴循环中的重要组成成分,不仅参与了机体营养物质的消化代谢,还作为一种信号分子和代谢调节因子,能够激活核受体和G蛋白偶联受体(GPCR)信号通路参与调节肝脏脂质、葡萄糖和能量平衡,维持机体代谢平衡。本文将结合近年来有关胆汁酸的研究进展,从胆汁酸的来源、在肠-肝轴中的循环以及胆汁酸在机体中的作用等方面进行综述,以加深对肠-肝轴重要性的理解。
[Abstract]:The interaction between the intestine and the liver forms the entero-hepatic axis, the disorder of the latter is an important cause of liver disease, and good intestinal homeostasis and liver protection play an important role in maintaining the stability of the body's internal environment. Bile acid (bile salt), as an important component of the enteric-hepatic axial circulation, not only participates in the digestion and metabolism of nutrients, but also acts as a signaling molecule and metabolic regulator. It can activate nuclear receptor and G protein coupled receptor (GPCR) signaling pathway to regulate liver lipid glucose and energy balance and maintain metabolic balance. In this paper, the source of bile acids, the circulation in the enterohepatic axis and the role of bile acids in the body are reviewed in order to understand the importance of the intestinal hepatic axis.
【作者单位】： 江苏省消化道营养与动物健康重点实验室南京农业大学消化道微生物研究室;
【基金】：国家重点基础研究发展计划项目(973项目)(2013CB127300) 国家自然科学基金(31430082) 江苏省自然科学基金(BK20130058)资助课题
【分类号】：R333
本文编号：2209084
[Abstract]:The interaction between the intestine and the liver forms the entero-hepatic axis, the disorder of the latter is an important cause of liver disease, and good intestinal homeostasis and liver protection play an important role in maintaining the stability of the body's internal environment. Bile acid (bile salt), as an important component of the enteric-hepatic axial circulation, not only participates in the digestion and metabolism of nutrients, but also acts as a signaling molecule and metabolic regulator. It can activate nuclear receptor and G protein coupled receptor (GPCR) signaling pathway to regulate liver lipid glucose and energy balance and maintain metabolic balance. In this paper, the source of bile acids, the circulation in the enterohepatic axis and the role of bile acids in the body are reviewed in order to understand the importance of the intestinal hepatic axis.
【作者单位】： 江苏省消化道营养与动物健康重点实验室南京农业大学消化道微生物研究室;
【基金】：国家重点基础研究发展计划项目(973项目)(2013CB127300) 国家自然科学基金(31430082) 江苏省自然科学基金(BK20130058)资助课题
【分类号】：R333
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