姜黄素对大鼠糖尿病模型的影响

发布时间：2018-09-05 08:25

【摘要】：目的:探讨姜黄素对大鼠糖尿病模型的影响。方法:链脲佐菌素制造大鼠糖尿病模型,每组给以相应的药物进行治疗,观察NO、NOS、iNOS的水平以及胰腺的病理变化。结果:与模型组相比,在第30天时,姜黄素高(200mg/kg)、中(100mg/kg)剂量组明显降低大鼠的血糖水平,姜黄素200mg/kg组的血糖水平为9.4±2.67,姜黄素100mg/kg组的血糖水平为11.98±4.53;与模型组相比,姜黄素200mg/kg、100mg/kg组和二甲双胍250mg/kg组均可显著降低NO、NOS、iNOS水平,姜黄素200mg/kg组NO水平为79.26±22.49,NOS水平为18.32±2.60,i NOS水平为4.90±2.12,姜黄素100mg/kg组NO水平为73.54±33.77,NOS水平为19.21±2.64,iNOS水平5.02±2.03,二甲双胍250mg/kg组NO水平为70.39±31.68,NOS水平为17.21±2.99,i NOS水平为5.93±2.21;与模型组相比,姜黄素200mg/kg组胰岛中各类细胞胞浆丰富,胰岛体积明显增大。结论:姜黄素对早期糖尿病有显著的改善作用。
[Abstract]:Objective: to investigate the effect of curcumin on diabetic rats. Methods: streptozotocin was used to make diabetic model in rats. Each group was treated with corresponding drugs to observe the level of NO,NOS,iNOS and the pathological changes of pancreas. Results: compared with the model group, on the 30th day, curcumin high (200mg/kg) and middle (100mg/kg) groups significantly decreased the blood glucose level of rats, the blood glucose level of curcumin 200mg/kg group was 9.4 卤2.67, curcumin 100mg/kg group was 11.98 卤4.53, compared with model group. Curcumin 200 mg / kg and metformin 250mg/kg decreased NO,NOS,iNOS level significantly. The NO level of curcumin 200mg/kg group was 79.26 卤22.49nNOS (18.32 卤2.60iNOS), curcumin 100mg/kg (NO) was 19.21 卤2.64iNOS (5.02 卤2.03), metformin 250mg/kg (NO) was 17.21 卤2.99i NOS (5.93 卤2.21), and curcumin 100mg/kg was 4.90 卤2.12 (P < 0.05). In curcumin 200mg/kg group, the cytoplasm of all kinds of islets was abundant, and the volume of islets was obviously enlarged. Conclusion: curcumin can significantly improve early diabetes mellitus.
【作者单位】：河南中医药大学;Henan
【基金】：基金项目:河南省道地药材深加工工程技术研究中心(2013-94) 河南省高校科技创新团队(2012IRTSTHN011) 郑州市中医药转化医学重点实验室(121PYFZX1820) 郑州市科技创新团队(131PCXTD612) 河南中医学院中药新药创制与道地药材深加工协同创新中心[2012]188-2
【分类号】：R285.5;R-332

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