巴马小型猪脾虚痰浊证模型NEI网络相关指标水平变化的实验研究

发布时间：2018-11-01 10:38

【摘要】：目的:从神经内分泌免疫网络(NEI)角度研究脾虚痰浊证巴马小型猪脑肠肽和神经递质的影响。方法:将巴马小型猪随机分为正常组和模型组,施以每日冲刺跑步训练联合高脂单笼饲养干预,建立小猪脾虚痰浊证模型。应用酶联免疫法(Elisa)测定血清中皮质醇(COR)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、5-羟色胺(5-HT)、胰高血糖素样肽-1(GLP-1)、乙酰胆碱(Ach)和去甲肾上腺素(NE)水平。结果:与正常组比较,模型组小型猪脑肠肽、神经递质水平发生差异性变化。结论:脾虚痰浊证模型神经内分泌免疫网络中脑肠肽、神经递质失常,提示NEI是客观存在的。某一环节的失衡可能是出现脾虚痰浊证的病理机制之一。
[Abstract]:Aim: to study the effects of neuroendocrine and immune network (NEI) on intestinal peptides and neurotransmitters in small pig brain of spleen deficiency and phlegm turbid syndrome. Methods: Bama miniature pigs were randomly divided into normal group and model group. The model of spleen deficiency and phlegm turbid syndrome was established by daily sprint training combined with high fat single cage feeding intervention. Serum cortisol (COR), angiotensin 鈪，

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