持留菌产生及耐药分子机制的研究进展
发布时间：2018-11-07 11:19
【摘要】：持留菌或持留细胞(Persister)是指微生物在受到有效抗菌药物作用时,绝大部分微生物很快死亡,同时残留了一小部分代谢活动低下、具有同基因型多药物耐受(Multidrug Tolerance,MDT)特性的微生物亚群(sub-population)。持留菌与耐药菌(resistant mutant)是不同的概念,持留菌是表型变异株(Phenotypic Heterogeneity),其基因序列没有发生突变,最小抑菌浓度(Minimal Inhibitory Concentration,MIC)不会增大,但持留菌的存在却是慢性感染性疾病反复发作、迁延不愈的主要原因。国外已经开展了大量实验来研究持留菌产生及其抗生素耐药的机制,本文将对持留菌的生物学特性、产生机制、耐药机制和有效的抗菌策略等内容进行综述。
[Abstract]:Retention bacteria or retention cell (Persister) means that when microbes are exposed to effective antimicrobial agents, the majority of microbes die quickly, while a small fraction of metabolic activity remains low, and they have multiple drug tolerance to (Multidrug Tolerance, with the same genotype. MDT, a subgroup of microorganisms (sub-population). The concept of (resistant mutant) is different from that of resistant strains. Retention strain is a phenotypic variant strain (Phenotypic Heterogeneity), whose gene sequence does not mutate and minimum inhibitory concentration (Minimal Inhibitory Concentration,MIC) does not increase. However, the presence of residual bacteria is the main cause of repeated attacks of chronic infectious diseases. A large number of experiments have been carried out abroad to study the mechanism of antibiotic resistance and its production. In this paper, the biological characteristics, production mechanism, drug resistance mechanism and effective antimicrobial strategies of retained bacteria are reviewed.
【作者单位】： 成都中医药大学医学技术学院;
【基金】：四川省科技厅应用基础项目(课题编号:2015JY0159)
【分类号】：R378
本文编号：2316196
[Abstract]:Retention bacteria or retention cell (Persister) means that when microbes are exposed to effective antimicrobial agents, the majority of microbes die quickly, while a small fraction of metabolic activity remains low, and they have multiple drug tolerance to (Multidrug Tolerance, with the same genotype. MDT, a subgroup of microorganisms (sub-population). The concept of (resistant mutant) is different from that of resistant strains. Retention strain is a phenotypic variant strain (Phenotypic Heterogeneity), whose gene sequence does not mutate and minimum inhibitory concentration (Minimal Inhibitory Concentration,MIC) does not increase. However, the presence of residual bacteria is the main cause of repeated attacks of chronic infectious diseases. A large number of experiments have been carried out abroad to study the mechanism of antibiotic resistance and its production. In this paper, the biological characteristics, production mechanism, drug resistance mechanism and effective antimicrobial strategies of retained bacteria are reviewed.
【作者单位】： 成都中医药大学医学技术学院;
【基金】：四川省科技厅应用基础项目(课题编号:2015JY0159)
【分类号】：R378
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