宿主抗病毒因子BST-2抑制HBV释放的研究进展
发布时间：2018-11-08 12:40
【摘要】：BST-2(Bone marrow stromal antigen 2,BST-2)一种宿主内天然抗病毒因子,自2008年首次报道其具有抗人类免疫缺陷病毒(HIV-1)释放的功能,一直认为BST-2主要在细胞膜上限制病毒释放。最近发现BST-2对在细胞内部组装的乙型肝炎病毒(HBV),同样具有抑制作用,扩大了BST-2抗病毒作用的范围。并且BST-2在多囊泡体(MVB)中抑制HBV的释放与抑制HIV-1在细胞膜中释放的作用机制相似。同时发现HBV能够拮抗BST-2的限制作用,而HBV病毒中发挥作用的拮抗因子,目前有两个观点,一是HBV在肝细胞的特定条件下利用调节蛋白HBx拮抗BST-2的限制作用,另一观点认为包膜蛋白HBs对BST-2存在拮抗作用。本文重点概述和讨论了BST-2限制HBV病毒的最新研究进展。
[Abstract]:BST-2 (BST-2) is a natural anti-viral agent in a host. It has been reported for the first time in 2008 that it has the function of anti-human immunodeficiency virus (HIV-1) release, and it has been thought that BST-2 mainly restricts the release of virus on the cell membrane. BST-2 has recently been found to have an inhibitory effect on the hepatitis B virus (HBV) assembled inside the cell, and the range of the anti-viral action of BST-2 is expanded. and BST-2 inhibits the release of HBV in the multi-vesicles (MVB) and the mechanism of inhibiting the release of HIV-1 in the cell membrane. At the same time, it is found that HBV can antagonize the restriction of BST-2, and the antagonistic factors which play a role in the HBV virus have two points of view, one is that HBV is used to antagonize the restriction of BST-2 with the regulation protein HBx under the specific conditions of the liver cells, and the other is that the envelope protein HBs has an antagonistic effect on the BST-2. In this paper, the latest development of BST-2-restricted HBV virus is reviewed and discussed.
【作者单位】： 吉林大学第一医院艾滋病与病毒研究所;
【基金】：国家自然科学基金(31270202)
【分类号】：R373
，
本文编号：2318534
[Abstract]:BST-2 (BST-2) is a natural anti-viral agent in a host. It has been reported for the first time in 2008 that it has the function of anti-human immunodeficiency virus (HIV-1) release, and it has been thought that BST-2 mainly restricts the release of virus on the cell membrane. BST-2 has recently been found to have an inhibitory effect on the hepatitis B virus (HBV) assembled inside the cell, and the range of the anti-viral action of BST-2 is expanded. and BST-2 inhibits the release of HBV in the multi-vesicles (MVB) and the mechanism of inhibiting the release of HIV-1 in the cell membrane. At the same time, it is found that HBV can antagonize the restriction of BST-2, and the antagonistic factors which play a role in the HBV virus have two points of view, one is that HBV is used to antagonize the restriction of BST-2 with the regulation protein HBx under the specific conditions of the liver cells, and the other is that the envelope protein HBs has an antagonistic effect on the BST-2. In this paper, the latest development of BST-2-restricted HBV virus is reviewed and discussed.
【作者单位】： 吉林大学第一医院艾滋病与病毒研究所;
【基金】：国家自然科学基金(31270202)
【分类号】：R373
，
本文编号：2318534
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