太原汉族人群17个Y-STR基因座等位基因频率及遗传关系

发布时间：2018-11-13 19:05

【摘要】：目的研究太原汉族人群17个Y-STR等位基因的频率、遗传多态性分布、遗传距离和聚类分析及其在法医学应用研究。方法应用Y-filerTM试剂盒检测102例太原汉族无关男性个体的血样,运用3130 xl遗传分析仪进行基因分型,计算等位基因频率。应用相关分析软件,参考其他地区人群资料,对太原汉族群体的遗传距离和遗传关系进行研究。结果 17个Y-STR基因座共有137个等位基因。基因多样性在0.433 5-0.894 0之间。根据遗传距离分析发现,与公开发表的国内其他群体相关数据资料相比,太原汉族与北京汉族之间的遗传距离最小(0.001 7),与台湾泰雅族人群之间的距离最大(0.469 6);与其他少数民族相比,太原汉族与辽宁满族群体之间的遗传距离最小(0.001 4),与台湾泰雅族人群之间的距离最大(0.4696)。结论 17个Y-STR基因座在太原汉族群体中有较好的遗传多态性,且有较强的个体识别能力及非父排除能力,对建立Y染色体数据库和法医学实际检案都有重要的意义。
[Abstract]:Objective to study the frequency, genetic polymorphism, genetic distance and cluster analysis of 17 Y-STR alleles in Taiyuan Han population and their application in forensic medicine. Methods the blood samples of 102 unrelated men of Taiyuan Han nationality were detected by Y-filerTM kit. The allele frequency was calculated by 3130 xl genetic analyzer. The genetic distance and genetic relationship of Taiyuan Han population were studied by using correlation analysis software and referring to other population data. Results there were 137 alleles in 17 Y-STR loci. The genetic diversity ranged from 0.433 to 0.894 0. According to genetic distance analysis, the genetic distance between Taiyuan Han and Beijing Han was the smallest (0.001 7), compared with the published data of other populations in China. The distance between Taiya and Taiwan is the largest (0.469 6); Compared with other minorities, the genetic distance between Taiyuan Han and Liaoning Manchu population was the smallest (0.001 4), and the distance between Taiyuan Han and Taiwanese Atayal population was the largest (0.4696). Conclusion 17 Y-STR loci have good genetic polymorphisms in Taiyuan Han population, and have strong ability of individual recognition and non-paternal exclusion, which is of great significance for the establishment of Y chromosome database and forensic medical practice.
【作者单位】：太原市公安局刑侦支队技术处DNA室;山西医科大学法医学院;山西医科大学公共卫生学院流行病教研室;
【基金】：山西医科大学科技创新基金资助项目(40)
【分类号】：D919.6;Q987

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