几种新现人体隐孢子虫种和基因型流行现状

发布时间：2018-11-25 09:33

【摘要】：隐孢子虫是一种寄生于宿主胃肠道上皮细胞内的原虫。人感染后,免疫功能正常者,常引起自限性腹泻;但在高危人群(如儿童、老人和免疫缺陷者等)中可发生严重腹泻和肠外感染,尤其是艾滋病患者。目前,隐孢子虫的分子流行病学研究已鉴定了30个有效种和40多种基因型,其中21个隐孢子虫种和基因型在人体发现。人体隐孢子虫病多数由人隐孢子虫(C.hominis)和微小隐孢子虫(C.parvum)引起。火鸡隐孢子虫(C.meleagridis)、泛在隐孢子虫(C.ubiquitum)、猫隐孢子虫(C.felis)和犬隐孢子虫(C.canis)引起的隐孢子虫病例也逐渐增多。除此之外,随着人体隐孢子虫病分子流行病学数据的增加,在人体内鉴定到一些新的隐孢子虫和基因型。特对上述新现的人体隐孢子虫种和基因型的流行现状进行综述。
[Abstract]:Cryptosporidium is a parasite in the epithelial cells of the host gastrointestinal tract. After infection, people with normal immune function often cause self-limited diarrhea, but in high-risk groups (such as children, the elderly and people with immune deficiency, etc.), serious diarrhea and extraintestinal infection can occur, especially in AIDS patients. At present, 30 effective species and more than 40 genotypes have been identified in molecular epidemiology of Cryptosporidium, of which 21 have been found in humans. Human Cryptosporidiosis is mostly caused by human Cryptosporidium (C.hominis) and Cryptosporidium minima (C.parvum). The number of Cryptosporidium cases caused by Cryptosporidium (C.meleagridis), Cryptosporidium (C.ubiquitum), Cryptosporidium felis (C.felis) and Cryptosporidium canis (C.canis) increased gradually. In addition, with the increase of molecular epidemiological data of Cryptosporidiosis, some new Cryptosporidium and genotypes were identified in human body. The epidemic status of Cryptosporidium species and genotypes mentioned above is reviewed in this paper.
【作者单位】：哈尔滨医科大学寄生虫学教研室;中国疾病预防控制中心寄生虫病预防控制所世界卫生组织热带病合作中心科技部国家级热带病国际联合研究中心卫生部寄生虫病原与媒介生物学重点实验室;
【基金】：国家卫生和计划生育委员会2015公益性行业科研专项(No.201502021) 黑龙江省教育厅课题(No.12531266)联合资助~~
【分类号】：R382.3

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