细胞因子对骨骼肌细胞和胰岛β细胞的作用

发布时间：2019-01-06 12:57

【摘要】：背景:多种细胞因子对骨骼肌细胞的生长发育起重要作用,包括细胞因子、生长因子、炎性蛋白等。目的:探讨多种细胞因子的生物学特性及其对骨骼肌细胞及胰岛β细胞的影响。方法:以"细胞因子、脂联素、瘦素、内脂素、骨骼肌细胞和胰岛β细胞"为中文检索词,以"cytokine,adiponectin,leptin,visfatin,skeletal muscle cells,isletβcell"为英文检索词。在相关期刊论文和PubM ed数据库中检索2002至2015年的相关文章,共检索到文献253篇,排除重复和相似文献,最终纳入53篇进行分析。结果与结论:脂联素是最近发现的一种脂肪特异性蛋白质,可促进骨骼肌细胞摄取、储存和利用葡萄糖,从而提高胰岛素敏感性。瘦素对肌卫星细胞有激活作用,可以促进骨骼肌成肌细胞的增殖,对骨骼肌细胞生长和发育有重要作用。内脂素是一种多效细胞因子,广泛存在于骨骼肌、肝脏、骨髓中,具有调节炎症反应和免疫功能的作用,促进骨骼肌的葡萄糖吸收和葡萄糖的代谢,对骨骼肌细胞应激反应和信号转导有重要作用。
[Abstract]:Background: a variety of cytokines play an important role in the growth and development of skeletal muscle cells, including cytokines, growth factors, inflammatory proteins and so on. Aim: to investigate the biological characteristics of various cytokines and their effects on skeletal muscle cells and islet 尾 cells. Methods: "cytokines, adiponectin, leptin, endolipin, skeletal muscle cells and islet 尾 cells" were used as Chinese key words and "cytokine,adiponectin,leptin,visfatin,skeletal muscle cells,islet 尾 cell" as English key words. A total of 253 articles were retrieved from 2002 to 2015 in the full text database and PubM ed database of Chinese journals, excluding duplication and similarity, and 53 articles were included in the analysis. Results & conclusion: adiponectin is a recently discovered adipose specific protein which can promote the uptake, storage and utilization of glucose in skeletal muscle cells, thus enhancing insulin sensitivity. Leptin can activate muscle satellite cells, promote the proliferation of skeletal muscle myoblasts, and play an important role in the growth and development of skeletal muscle cells. Endolipin is a multipotent cytokine widely found in skeletal muscle, liver and bone marrow. It can regulate inflammatory reaction and immune function and promote glucose absorption and metabolism of skeletal muscle. It plays an important role in stress response and signal transduction of skeletal muscle cells.
【作者单位】：忻州师范学院;
【基金】：山西省2014年大学生创业创新训练基金项目,课题名称:减肥物质结合运动减肥效用研究山西省忻州师范学院重点建设学科专项课题项目(xk201403)~~
【分类号】：R329.2

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