细胞内吞和自噬对MMPs调节的研究进展
发布时间：2019-03-01 12:00
【摘要】：真核细胞以一种复杂而高效的膜转运网络维持细胞内外物质循环和新旧更替。Rab蛋白做为全局性调节因子,参与从膜发生、成熟到膜融合的几乎所有步骤,将各种膜转运形式如内吞和自噬等联系在一起。内吞能够调节细胞表面分子的分布和功能状态,而进入胞浆的蛋白可经由内吞体循环,或者在自噬小体作用下被降解利用,辅助细胞度过饥饿、缺氧等危机。基质金属蛋白酶(MMPs)在细胞表面的分布和活性受到内吞调节,并且MMPs在细胞内循环和运输与Rab蛋白关系密切。在本文作者简要回顾细胞内吞和自噬的内在关联,阐述膜结构变动对MMPs分布和功能状态的调节作用。
[Abstract]:Eukaryotic cells use a complex and efficient membrane transport network to maintain intracellular and extracellular material circulation and replacement. Rab protein, as a global regulatory factor, is involved in almost all the steps from membrane formation to maturation to membrane fusion. Various membrane transport forms such as endocytosis and autophagy are associated. Endocytosis can regulate the distribution and functional state of molecules on the cell surface, and the protein entering into the cytoplasm can be circulating through endocytosis, or be degraded under the action of autophagy, and the helper cells can survive the crisis of starvation and hypoxia. The distribution and activity of matrix metalloproteinases (MMPs) on the cell surface are regulated by endocytosis, and the intracellular circulation and transport of MMPs are closely related to Rab protein. In this paper, we briefly review the intrinsic relationship between endocytosis and autophagy, and expound the regulatory effects of membrane structural changes on the distribution and functional state of MMPs.
【作者单位】： 东南大学医学院病理学与病理生理学系;
【基金】：国家自然科学基金资助项目(81370868) 中央高校基本科研业务费专项资金项目 江苏省普通高校研究生科研创新计划资助项目(KYLX_0197)
【分类号】：R363
[Abstract]:Eukaryotic cells use a complex and efficient membrane transport network to maintain intracellular and extracellular material circulation and replacement. Rab protein, as a global regulatory factor, is involved in almost all the steps from membrane formation to maturation to membrane fusion. Various membrane transport forms such as endocytosis and autophagy are associated. Endocytosis can regulate the distribution and functional state of molecules on the cell surface, and the protein entering into the cytoplasm can be circulating through endocytosis, or be degraded under the action of autophagy, and the helper cells can survive the crisis of starvation and hypoxia. The distribution and activity of matrix metalloproteinases (MMPs) on the cell surface are regulated by endocytosis, and the intracellular circulation and transport of MMPs are closely related to Rab protein. In this paper, we briefly review the intrinsic relationship between endocytosis and autophagy, and expound the regulatory effects of membrane structural changes on the distribution and functional state of MMPs.
【作者单位】： 东南大学医学院病理学与病理生理学系;
【基金】：国家自然科学基金资助项目(81370868) 中央高校基本科研业务费专项资金项目 江苏省普通高校研究生科研创新计划资助项目(KYLX_0197)
【分类号】：R363
【相似文献】
相关期刊论文 前9条
1 陈莉;朱建伟;;在癌细胞中下调皮质肌动蛋白使细胞内吞作用减弱[J];基础医学与临床;2008年06期
2 雷国华,朴英杰,吴建春;测量细胞内吞过程中膜受体流动性的新方法[J];第一军医大学学报;1998年01期
3 秦晓松;刘勇;吴丽娜;刘建华;王丹丹;;Nephrin分子细胞内吞转运途径的研究[J];中国细胞生物学学报;2010年04期
4 王宪锋;弓形虫受体介导的细胞内吞作用[J];国外医学(寄生虫病分册);2002年03期
5 刘莹;毕强;王国丽;徐鸿瀗;刘楠启;;Pkh1/2-Pil1信号调节酵母细胞内吞[J];中国生物化学与分子生物学报;2011年04期
6 魏强,吴满平,陈佩芳,梅美珍,高秀健;大鼠肝窦状隙细胞内吞高密度脂蛋白-2的逆向胞饮作用[J];上海医科大学学报;1996年05期
7 李树春;王槐;王桂萍;满序聪;;mRSD-9基因参与细胞内吞功能的初步研究[J];中国病理生理杂志;2011年10期
8 徐冶;李质馨;曹慧玲;王弘s，
本文编号：2432403
本文链接：https://www.wllwen.com/xiyixuelunwen/2432403.html
最近更新
教材专著
