Advancement in regional immunity and its clinical implicatio

发布时间：2019-03-13 21:21

【摘要】：Organs in our body have formed their own unique immune surveillance system that is finely tuned by in situ milieu. Sequestrated tissue-resident immune cells differ from their counterparts in circulation and participate in tissue physiological activities and the maintenance of local homeostasis. Dysregulation of regional immunity leads to organ-specific inflammatory injuries. Here we review the recent developments in the field of tissue-resident immune cells and organ-specific regional immunity, and discuss their clinical implication.
[Abstract]:Organs in our body have formed their own unique immune surveillance system that is finely tuned by in situ milieu. Sequestrated tissue-resident immune cells differ from their counterparts in circulation and participate in tissue physiological activities and the maintenance of local homeostasis. Dysregulation of regional immunity leads to organ-specific inflammatory injuries. Here we review the recent developments in the field of tissue-resident immune cells and organ-specific regional immunity, and discuss their clinical implication.
【作者单位】： Department
【基金】：supported by grants from the National Natural Science Foundation of China (81788104, 81630044, 81601432, 81550023, 81771763) the National Science Fund for Distinguished Young Scholars of China (81325019) National Key Research and Development Program: "Precise Medical Research”(2016YFC0903900) Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFM2016-12M-1-003, 2017-12M-1-008, 2016-12M-1-008) 2016 Peking Union Medical College Hospital Fund for Junior Faculty (pumch-2016-2.1)
【分类号】：R392

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