靶向哺乳动物细胞线粒体的核酸转运
发布时间：2019-06-02 11:11
【摘要】：线粒体DNA(mitochondrial DNA,mtDNA)的遗传性突变和缺陷是多种线粒体功能失调相关疾病的根本原因。靶向线粒体递送核酸,可从根本上纠正mtDNA突变、挽救mtDNA损伤、阻断疾病进程。哺乳细胞内线粒体的核酸转运途径与细胞核的基因转染大不相同。该文综述了向哺乳动物细胞线粒体递送DNA和RNA(tRNA、rRNA、mRNA和反义RNA)的有效策略,并对其存在问题和发展趋势做一阐述。
[Abstract]:The genetic mutation and defect of mtDNA (DNA (mitochondrial DNA,mtDNA) are the root causes of many diseases related to mtDNA dysfunction. The delivery of nucleic acid to mitochondria can fundamentally correct mtDNA mutation, save mtDNA damage and block the process of disease. The nucleic acid transport pathway of mitochondria in lactation cells is very different from that of nuclear gene transfer. In this paper, the effective strategies of delivering DNA and RNA (tRNA,rRNA,mRNA and antisense RNA) to mammal cells are reviewed, and their existing problems and development trends are described.
【作者单位】： 西南大学药学院;
【基金】：国家自然科学基金资助项目(No 81273416) 教育部高校基本科研业务费(No XDJK2013A030);教育部回国人员启动基金;教育部新世纪优秀人才支持计划资助
【分类号】：R3416
本文编号：2491049
[Abstract]:The genetic mutation and defect of mtDNA (DNA (mitochondrial DNA,mtDNA) are the root causes of many diseases related to mtDNA dysfunction. The delivery of nucleic acid to mitochondria can fundamentally correct mtDNA mutation, save mtDNA damage and block the process of disease. The nucleic acid transport pathway of mitochondria in lactation cells is very different from that of nuclear gene transfer. In this paper, the effective strategies of delivering DNA and RNA (tRNA,rRNA,mRNA and antisense RNA) to mammal cells are reviewed, and their existing problems and development trends are described.
【作者单位】： 西南大学药学院;
【基金】：国家自然科学基金资助项目(No 81273416) 教育部高校基本科研业务费(No XDJK2013A030);教育部回国人员启动基金;教育部新世纪优秀人才支持计划资助
【分类号】：R3416
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1 林岚,沈岩;穿梭蛋白-细胞核与细胞浆之间物质信息传递的载体[J];国外医学(分子生物学分册);1999年03期
，本文编号：2491049
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