普乐士泰胶囊对慢性非细菌性前列腺炎模型大鼠的改善作用

发布时间：2019-06-03 14:59

【摘要】：目的:考察普乐士泰胶囊对慢性非细菌性前列腺炎(CNP)模型大鼠的改善作用。方法:将60只大鼠随机分为假手术组(蒸馏水)、模型组(蒸馏水)、普乐安片组(阳性对照,2 g/kg)和普乐士泰胶囊高、中、低剂量组(16、8、4 g/kg),除假手术组外的其余5组大鼠均注射消痔灵注射液0.2 m L复制CNP模型。造模7 d后ig相应药物,每日1次,连续45 d。末次给药后24 h,肉眼观察前列腺的病变并称定其湿质量;显微镜下进行白细胞(WBC)计数和卵磷脂小体(SPL)计数,并对前列腺组织切片进行病理观察。结果:与假手术组比较,模型组大鼠前列腺局部出现灰白色结节、腺体与周围组织发生粘连等病变;腺体湿质量和前列腺组织中WBC、SPL计数均显著增加(P0.01);显微镜下可见前列腺间质中有明显充血、水肿及多种炎症细胞浸润。与模型组比较,普乐安片组和普乐士泰胶囊各剂量组大鼠前列腺局部灰白色结节减少、腺体与周围组织粘连程度减轻;腺体湿质量和前列腺组织中WBC、SPL计数均显著减少(P0.01);显微镜下可见病理变化得到不同程度改善,且以普乐士泰胶囊高剂量组改善最为明显,前列腺组织间质中仅有轻度充血、水肿和少量炎症细胞浸润。结论:普乐士泰胶囊对CNP模型大鼠有一定的改善作用。
[Abstract]:Objective: To study the effect of prustitai capsule on rats with chronic non-bacterial prostatitis (CNP). Methods:60 rats were randomly divided into sham operation group (distilled water), model group (distilled water), Pu 'an group (positive control,2 g/ kg), and high, middle and low dose group (16,8,4 g/ kg). The CNP model was duplicated with the injection of 0.2m L of the injection of Xiaozhiling injection in the remaining 5 groups except the sham-operation group. The pathological changes of the prostate were observed by naked eyes at 24 h after the last dose, and the white blood cell (WBC) count and the lecithin body (SPL) were counted under the microscope, and the pathological observation of the prostate tissue sections was performed. Results: Compared with the sham-operation group, the local appearance of gray-white nodules in the prostate of the model group and the adhesion of the glands to the surrounding tissues were significantly increased (P0.01), and there was marked congestion in the prostate stroma under the microscope. Edema and multiple inflammatory cell infiltration. Compared with the model group, the local off-white nodules of the prostate were reduced, the degree of adhesion between the gland and the surrounding tissues was reduced, and the number of WBC and SPL in the gland wet and prostate tissues was significantly reduced (P0.01). The pathological changes under the microscope were improved to a different extent, and the most obvious improvement was made in the high dose group of the prustitai capsule, and only mild congestion, edema and a small amount of inflammatory cell infiltration were found in the interstitial tissue of the prostate. Conclusion: The Pule-tai capsule has a certain improvement effect on the CNP model rats.
【作者单位】：广西中医药大学第一附属医院药学部;广西中医药大学第一附属医院胃肠肛门中心;广西中医药大学第一附属医院检验科;广西中医药大学第一附属医院男科;
【基金】：广西壮族自治区卫生厅中医药科技专项课题;广西壮族自治区卫生厅医院制剂遴选课题(No.GZYZ1105)
【分类号】：R285.5;R-332

【参考文献】