血管自适应生长的稳定性

发布时间：2019-06-15 02:42

【摘要】：在动物和人类的整个生命过程中,血管的结构会随着身体组织代谢需求的变化而进行连续的自适应调节。这些调节包括对血管内径的大小,血管的壁厚,身体组织中毛细血管的数量及密度等的调节。已有的研究表明,血管内壁上的血流剪切力会刺激血管内径变大,血管自身有固有的缩小趋势,在血管内径大小的自适应调节中,这两个刺激因素扮演着重要角色。然而仅有这两个刺激的自适应调节是不稳定的,并联的血管网络会退化为仅剩一条血管的通路。在这篇文章中,我们引入毛细血管前括约肌的调节作用,毛细血管前括约肌存在于微血管和毛细血管之间,括约肌的舒张和收缩作用就相当于电路里开关的作用。用包含固有缩小趋势,剪切力和毛细血管前括约肌三个调节作用的模型来模拟血管的自适应调节,可以证明血管网络的自适应调节变得稳定了。我们的一些结果有可能解释高血压等一些血管病的病因,还可以为血管模拟实验提供一些参考。
[Abstract]:In the whole life process of animals and human beings, the structure of blood vessels will be adjusted continuously and adaptively with the change of metabolic needs of body tissue. These adjustments include the size of the vessel diameter, the wall thickness of the vessel, the number and density of capillaries in the body tissue, and so on. Previous studies have shown that the shear force of blood flow on the inner wall of blood vessels can stimulate the diameter of blood vessels to become larger and the vessels themselves have an inherent tendency to shrink. These two stimulants play an important role in the adaptive regulation of the diameter of blood vessels. However, only the adaptive regulation of these two stimuli is unstable, and the parallel vascular network will degrade into only one vascular pathway. In this paper, we introduce the regulation of anterior capillary sphincter. Anterior capillary sphincter exists between microvessels and capillaries, and the relaxation and contraction of sphincter is equivalent to that of switch in circuit. It can be proved that the adaptive regulation of vascular network is stable by simulating the adaptive regulation of blood vessels by using the model of inherent reduction trend, shear force and anterior capillary sphincter. Some of our results may explain the etiology of some vascular diseases, such as hypertension, and can also provide some references for vascular simulation experiments.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R311

【共引文献】