放射性心脏“炎性-纤维化”损伤大鼠模型的建立与评估
【文章页数】:9 页
【部分图文】:
图1RIHD大鼠心肌病理变化及病理评分1d1week2weeks4weeks6weeks1.00.50.0PathAB
·1072·第二军医大学学报2019年10月,第40卷2.2.2心脏病理损伤评分对照组大鼠心肌细胞排列整齐,细胞核蓝染,细胞质呈淡红色;模型组大鼠心肌细胞水肿明显、排列紊乱,心肌细胞核轻度固缩、染色加深,出现少量异型细胞核,可见炎性渗出(图1A)。对照组大鼠各时间点心肌病理损伤评....
图2RIHD大鼠心肌胶原染色和CVF变化AB1d1week2weeks4weeks6weeks0.10.0
ndpathologyinjuryscoresofRIHDratsA:H-Estainingwasperformed1weekafterirradiation;B:Pathologyinjuryscorewasobtainedatday1,andweek1,2,4and6afte....
图4免疫组织化学染色检测RIHD大鼠心肌炎性因子和纤维化因子表达Fig4ImmunohistochemistrystainingofinflammatoryandfibroticfactorsinmyocardialtissuesofRIHDratsRIHD:Radiation-inducedheartdamage;PI:Pre-irradiation;NF-κB:NuclearfactorκB;TNF-α:Tumornecrosisfactorα;TGF-β1:Transforminggrowthfactorβ1;ColⅠ:CollagentypeⅠ;ColⅢ:CollagentypeⅢ.Originalmagnification:×400ColⅢ
·1073·2.2.5炎性-纤维化因子检测结果大鼠心肌组织免疫组织化学染色结果(图4、表1)显示,炎性因子NF-κBp65、NF-κBp50、TNF-α均在细胞质中表达,模型1d、1周、2周、4周组大鼠心肌NF-κBp65、NF-κBp50、TNF-α表达量与照射前相比均增加,差....
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