T细胞斑点试验、结核蛋白芯片、抗酸染色涂片和结核菌素试验对肺结核病诊断价值的比较

发布时间：2018-01-03 05:19

本文关键词：T细胞斑点试验、结核蛋白芯片、抗酸染色涂片和结核菌素试验对肺结核病诊断价值的比较　出处：《中国现代医学杂志》2015年11期 　论文类型：期刊论文

【摘要】：目的对T细胞斑点试验(T-SPOT.TB)、结核蛋白芯片(GCT)、抗酸染色涂片(AFS)及结核菌素试验(PPD)检测结核分枝杆菌的方法进行比较,评价不同方法在肺结核病诊断中的临床应用价值。方法回顾性分析2013年1月-2014年6月湖北省宜昌市第三人民医院收治的疑似肺结核患者206例,其中确诊肺结核患者134例;非结核患者72例。用上述4种方法分别检测206例患者,分析4种方法诊断肺结核病的敏感性、特异性,并比较T-SPOT.TB与GCT、AFS与PPD试验诊断肺结核的准确性。结果 T-SPOT.TB、GCT、AFS及PPD试验检测肺结核的敏感性分别为86.57%、52.24%、31.34%和55.97%;特异性分别为90.28%、81.94%、98.61%和66.67%。结论 T-SPOT.TB与GCT、AFS及PPD试验比较,有简便、快速、敏感性高和特异性强等优点,是临床结核病快速诊断的有效检测方法。
[Abstract]:The purpose of T cell spot test (T-SPOT.TB), tuberculosis protein chip (GCT), acid fast stain (AFS) and tuberculin test (PPD) method comparing the detection of Mycobacterium tuberculosis and evaluate the clinical application value of different methods in the diagnosis of pulmonary tuberculosis. Methods Retrospective analysis of January 2013 -2014 year in June admitted to Yichang Third People's Hospital of Hubei province suspected pulmonary tuberculosis patients in 206 cases, including 134 cases of pulmonary tuberculosis patients; 72 cases of non tuberculosis patients. 206 patients were detected by the above 4 methods, analysis of 4 kinds of methods of diagnosis of pulmonary tuberculosis sensitivity, specificity, and accuracy of AFS T-SPOT.TB compared with GCT, and PPD test in the diagnosis of pulmonary tuberculosis. T-SPOT.TB, GCT, AFS and PPD sensitivity test for the detection of pulmonary tuberculosis were 86.57%, 52.24%, 31.34% and 55.97%; the specificity was 90.28%, 81.94%, 98.61% and 66.67%. T-SPOT.TB and GCT AFS conclusion, and PPD test It has the advantages of simple, rapid, high sensitivity, and strong specificity, which is an effective detection method for the rapid diagnosis of tuberculosis.

【作者单位】：湖北省宜昌市第三人民医院肺病科;
【分类号】：R521
【正文快照】： 我国是结核病高发国家之一,2000年全国结核病流行病学调查显示,全国受结核菌感染人数约5.5亿,其中传染性肺结核病患者150万人。随着耐药结核菌株增多、HIV合并结核感染、人口流动增大等问题的出现,结核病疫情日趋严重。如何快速、准确诊断结核病一直是临床关注的问题[1]。近年

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