社区获得性下呼吸道感染患者病原菌及其耐药性变迁分析

发布时间：2018-01-04 19:29

本文关键词：社区获得性下呼吸道感染患者病原菌及其耐药性变迁分析　出处：《中华医院感染学杂志》2016年13期 　论文类型：期刊论文

【摘要】：目的探讨社区获得性下呼吸道感染患者病原菌及耐药性变迁,为临床治疗社区获得性下呼吸道感染抗菌药物选择提供参考依据。方法收集医院2012年1月-2014年12月所有社区获得性下呼吸道感染患者标本进行病原菌分离,采用法国生物梅里埃公司生产VITEK-32细菌检定仪进行病原菌鉴定,K-B纸片琼脂扩散法进行药敏试验,采用SPSS18.0软件对数据进行统计分析。结果 2012-2014年共分离病原菌720株,2014年与2012年、2013年比较革兰阳性菌与真菌有所上升,革兰阴性菌有所下降。肠杆菌科细菌对美罗培南、亚胺培南碳青霉烯类抗菌药物敏感,大肠埃希菌的的耐药率普遍低于肺炎克雷伯菌。铜绿假单胞菌对亚胺培南的耐药率升高显著,鲍曼不动杆菌对亚胺培南保持敏感。葡萄球菌对万古霉素非常敏感,对青霉素具有很高的耐药率。结论不合理使用抗菌药物是下呼吸道感染病原菌及耐药率变迁的主要因素,应对下呼吸道感染病原菌及耐药率进行监测,合理的选择抗菌药物,要适当的减少预防性用药,以提高感染性疾病的治疗效果。
[Abstract]:Objective to investigate the changes of pathogens and drug resistance in community-acquired lower respiratory tract infection patients. Methods all community acquired lower respiratory tract infection specimens were collected from January 2012 to December 2014 in our hospital for the selection of antibiotics for the treatment of community-acquired lower respiratory tract infection. Isolation of pathogenic bacteria. The identification of pathogenic bacteria was carried out by using the VITEK-32 bacteriostat produced by Bio-Merriere Company of France. The susceptibility test was carried out by Agar diffusion method. The data were analyzed by SPSS18.0 software. Results 720 strains of pathogenic bacteria were isolated in 2012-2014, 2014 and 2012. In 2013, Gram-positive bacteria and fungi increased, and Gram-negative bacteria decreased. Enterobacteriaceae bacteria were sensitive to meropenem and imipenem carbapenem antibiotics. The resistance rate of Escherichia coli to imipenem was generally lower than that of Klebsiella pneumoniae. The resistance rate of Pseudomonas aeruginosa to imipenem was higher than that of Klebsiella pneumoniae. Acinetobacter baumannii is sensitive to imipenem. Staphylococcus is very sensitive to vancomycin. Conclusion irrational use of antimicrobial agents is the main factor of pathogenic bacteria and the change of drug resistance rate of lower respiratory tract infection. It is necessary to monitor the pathogenic bacteria and drug resistance rate of lower respiratory tract infection. The rational choice of antimicrobial drugs, should be appropriate to reduce prophylactic use, in order to improve the treatment of infectious diseases.
【作者单位】：河南大学淮河医院呼吸与危重症科;河南大学淮河医院感染科;
【基金】：河南省自然科学基金资助项目(HN28123)
【分类号】：R56
【正文快照】： 康造成严重威胁[1]。由于大量抗菌药物的广泛性应用,使病原菌及耐药性不断发生变迁[2]。为指导临床合理使用抗菌药物提供依据,本研究对2012-2014年医院社区获得性下呼吸道感染病原菌及耐药率进行了分析,现报道如下。1材料与方法1.1材料来源收集医院2012年1月-2014年12月所有社

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