CT血管成像对COPD支气管动脉变化与肺功能关系的研究

发布时间：2018-01-14 02:15

本文关键词：CT血管成像对COPD支气管动脉变化与肺功能关系的研究　出处：《临床放射学杂志》2015年05期 　论文类型：期刊论文

【摘要】：目的利用CT血管成像技术(CTA)研究慢性阻塞性肺疾病(COPD)患者支气管动脉的显示及支气管动脉管径与肺功能(PFT)指标间的关系,探索COPD支气管动脉变化与气道重塑的关系。方法回顾性分析43例COPD患者的支气管动脉CTA图像,利用多平面重组(MPR)、最大密度投影(MIP)及容积再现(VR)对患者支气管动脉重建,统计支气管动脉支数,评价支气管动脉的显示情况,测量肺门水平各支支气管动脉管径,并分析支气管动脉管径与肺功能指标(FEV1,FEV1%,FVC,FEV1/FVC)的关系。结果共显示支气管动脉102支。左支气管动脉41支(40.2%),平均管径1.51 mm。右支气管动脉61支(59.8%),平均管径1.98 mm。右支气管动脉管径较左侧粗,具有统计学意义(P=0.001)。右支气管动脉管径与肺功能指标FEV1(r=-0.468,P0.001)、FEV1%(r=-0.476,P0.001)、FVC(r=-0.381,P=0.002)、FEV1/FVC(r=-0.468,P0.001)均呈负相关。左支气管动脉管径与FEV1(r=-0.314,P=0.046)、FEV1%(r=-0.357,P=0.022)呈负相关,与FVC(r=-0.265,P=0.094)及FEV1/FVC(r=-0.284,P=0.072)无显著相关性。结论 CTA可清晰显示COPD患者支气管动脉。右支气管动脉管径较左侧粗。右支气管动脉管径均与肺功能指标呈负相关。左支气管动脉管径与FEV1、FEV1%预呈负相关,说明支气管动脉与COPD的气道结构重塑关系密切。
[Abstract]:Objective to study the relationship between bronchial artery diameter and pulmonary function index (PFTs) in patients with chronic obstructive pulmonary disease (COPD) by CT angiography (CTAA). To explore the relationship between bronchial artery changes and airway remodeling in COPD. Methods the CTA images of bronchial artery in 43 patients with COPD were analyzed retrospectively. Maximum density projection (MIP) and volumetric reconstruction (VRV) were used to reconstruct the bronchial artery, count the branches of the bronchial artery, evaluate the display of the bronchial artery, and measure the diameter of each branch of the bronchial artery at the hilar level. The diameter of bronchial artery and pulmonary function were analyzed and the FVC of FEV1 and FEV1 were analyzed. Results 102 bronchial arteries and 41 left bronchial arteries were found. The mean diameter of the right bronchial artery was 1.51 mm. The diameter of the right bronchial artery was 1.98 mm. The diameter of the right bronchial artery was thicker than that of the left. The diameter of the right bronchial artery and the pulmonary function index FEV1r-0.468 P0.001P0.001 / FEV1 were found to be the same as that of FEV1 and FEV1 / 0.476.The diameter of the right bronchial artery and the pulmonary function were significantly higher than that of the control group (P < 0.05). P0.001FVCnr ~ (-0.381N) P0.002 / FV ~ (1 /) FVC ~ (1 /) -0.468 (P = 0. 002), P = 0. 001 (P = 0. 001). There was a negative correlation between the diameter of left bronchial artery and FEV _ 1 ~ r ~ (-0.314) P ~ (0.046) and FEV _ 1 / r ~ (-0.357). There was a negative correlation between FEV1/FVC(r=-0.284 and FEV1/FVC(r=-0.284. P0. 072). No significant correlation. Conclusion. The diameter of the right bronchial artery was thicker than that of the left, the diameter of the right bronchial artery was negatively correlated with the pulmonary function index, and the diameter of the left bronchial artery was associated with FEV1. FEV 1% was negatively correlated with airway remodeling of COPD.
【作者单位】：第二军医大学附属上海长征医院影像科;
【基金】：国家自然基金资助项目(基金编号:81271572)
【分类号】：R563.9;R816.4
【正文快照】： 支气管动脉是支气管的营养动脉,长期慢性炎症会导致支气管动脉管径增粗,动脉压力增高。慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)以不可逆气流障碍为特征,患者小气道壁结构重塑,对慢性炎症具有高反应性[1],缺氧与慢性炎症刺激会导致支气管动脉代偿性增粗

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