低分子肝素对社区获得性肺炎临床疗效的影响

发布时间：2018-01-15 06:04

本文关键词：低分子肝素对社区获得性肺炎临床疗效的影响　出处：《中国呼吸与危重监护杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的观察低分子肝素辅助治疗对社区获得性肺炎临床疗效的影响。方法收集2013年1月至2015年3月哈尔滨医科大学附属第四医院呼吸内科住院的社区获得性肺炎患者共78例,随机分为常规治疗组和低分子肝素联合治疗组。两组患者均给予抗感染、对症等治疗,其中低分子肝素联合治疗组在常规抗生素治疗的基础上皮下注射低分子肝素,每日1次,7 d为一个疗程。所有患者统计年龄、性别、病情严重程度,记录治疗前及治疗后第1 d、第3 d和第7 d的血常规、C反应蛋白、血沉的变化,并统计分析两组上述3种指标随病情严重程度的变化。结果与常规治疗组比较,低分子肝素联合治疗组C反应蛋白、血沉在治疗后第3 d明显下降,白细胞计数在治疗后第7 d明显下降,差异均有统计学意义(P0.05)。对于中、重度的社区获得性肺炎患者,与常规治疗组比较,低分子肝素联合治疗组C反应蛋白(治疗后第3 d)和白细胞计数(治疗后第7 d)均明显下降,差异均有统计学意义(P0.05)。结论低分子肝素联合常规治疗可明显提高社区获得性肺炎的临床疗效。
[Abstract]:Objective to observe the effect of low molecular weight heparin (LMWH) adjuvant therapy on the clinical efficacy of community-acquired pneumonia (CPAP). Methods from January 2013 to March 2015, we collected the community in the respiratory department of 4th affiliated Hospital of Harbin Medical University. There were 78 cases of acquired pneumonia. They were randomly divided into routine treatment group and low-molecular-weight heparin combined treatment group. Both groups were given anti-infection and symptomatic treatment. Low molecular weight heparin combined therapy group was subcutaneously injected with low molecular weight heparin on the basis of routine antibiotic therapy, 7 days a day as a course of treatment. All patients were counted for age, sex and severity of the disease. The changes of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were recorded before and after treatment on the 1st, 3rd and 7th day after treatment. The changes of the above three indexes with the severity of the disease were statistically analyzed. Results compared with the routine treatment group, the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) of the low molecular weight heparin (LMWH) combined treatment group decreased significantly on the 3rd day after treatment. The white blood cell count decreased significantly on the 7th day after treatment, and the difference was statistically significant (P 0.05). For the moderate and severe patients with community-acquired pneumonia, it was compared with the routine treatment group. The C-reactive protein (3 d) and white blood cell count (7 d) were significantly decreased in the low molecular weight heparin (LMWH) combined treatment group. Conclusion low molecular weight heparin combined with routine therapy can significantly improve the clinical efficacy of community-acquired pneumonia.
【作者单位】：哈尔滨医科大学附属第四医院呼吸内科;
【分类号】：R563.1
【正文快照】： 社区获得性肺炎(CAP)是临床最常见的下呼吸道感染性疾病,是社区人群,尤其是儿童、老年人和免疫缺陷人群的常见病和多发病,也是其经济负担增加的主要原因,严重威胁人类的健康[1]。CAP的发病机制除了微生物感染产生的直接毒性外,机体的炎症反应与凝血功能均参与其中。病原微生物

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