Nogo-B在慢性阻塞性肺病合并肺心病中的变化及意义

发布时间：2018-01-19 01:11

本文关键词： 慢性阻塞性肺病肺心病 Nogo-B 脑钠肽N端前体　出处：《实用医学杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的:观察Nogo-B在慢性阻塞性肺病(COPD)合并慢性肺源性心脏病患者血液中的变化,并分析其相关性及意义。方法:住院COPD患者77例,分为COPD组(38例)和COPD合并肺心病组(CP组,39例),另选取正常健康者20例作为正常组。分别检测血浆Nogo-B、NT-pro BNP水平。结果:Nogo-B、NT-pro BNP在COPD组[(22.41±6.62)pg/m L、(91.32±8.77)pg/m L]高于正常组[(7.02±2.55)pg/m L、(20.34±5.72)pg/m L];在CP组[(51.45±8.75)pg/m L、(506.28±14.91)pg/m L]高于COPD组,组间比较差异均有统计学意义(P0.01)。Nogo-B与右室内径呈正相关(r=0.745,P0.01),与左室内径/右室内径(LV/RVD)呈负相关(r=-0.591,P0.01);Nogo-B与NT-pro BNP呈正相关(r=0.725,P0.01),与PO2呈负相关(r=-0.415,P0.01)。COPD继发肺心病ROC曲线示Nogo-B、NT-pro BNP的曲线下面积为0.683、0.655(均P0.05)。结论:Nogo-B在COPD继发肺心病的发生过程中起着重要作用;Nogo-B与NT-pro BNP对COPD继发肺心病的评估有一定意义。
[Abstract]:Objective: to observe the changes of Nogo-B in the blood of patients with chronic obstructive pulmonary disease (COPD) and chronic pulmonary heart disease (COPD), and to analyze its correlation and significance. Methods: 77 COPD patients were hospitalized. The patients were divided into COPD group (n = 38) and COPD combined with cor pulmonale group (n = 39) and normal control group (n = 20). Plasma Nogo-B was measured respectively. NT-pro BNP level. Results: Nogo-Bon NT-pro BNP in COPD group. [22.41 卤6.62pg / mL 91.32 卤8.77pg / mL] was higher than normal group. [7.02 卤2.55 g / mL 20.34 卤5.72 g / mL in CP group. [51.45 卤8.75 渭 g / mL was higher than that in COPD group (506.28 卤14.91 渭 g / mL). The difference between the two groups was statistically significant (P 0.01). Nogo-B was positively correlated with the right ventricular diameter (P 0.01). There was a negative correlation between left ventricular diameter and right ventricular internal diameter (LVR / RVD). There was a positive correlation between Nogo-B and NT-pro BNP, but a negative correlation with PO2. The ROC curve showed that the area under the curve of NT-pro BNP was 0.683. Conclusion Nogo-B plays an important role in the pathogenesis of cor pulmonale secondary to COPD. Nogo-B and NT-pro BNP have some significance in the evaluation of COPD secondary cor pulmonale.
【作者单位】：徐州医学院附属医院呼吸科;
【基金】：徐州医学院附属医院科研课题(编号:2013104019)
【分类号】：R563.9;R541.5
【正文快照】： Nogo-B是网状蛋白家族4中分布最广的成员,网状蛋白家族(reticulon protein family,Rtn)为一种主要定位于内质网的蛋白质,功能主要涉及内质网-高尔基体转运、囊泡形成、内质网膜形态发生等过程,从而在调节细胞凋亡、细胞再生等病理生理过程中发挥重要作用[1]。Nogo-B及其信号通

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