热毒宁对重症肺炎患者血浆可溶性髓系细胞触发受体1、白细胞介素10水平变化与相关性研究

发布时间：2018-01-19 20:45

本文关键词： 热毒宁重症肺炎 sTREM- IL- 呼吸功能　出处：《辽宁中医杂志》2016年08期 　论文类型：期刊论文

【摘要】：目的:探讨热毒宁对重症肺炎患者血浆可溶性髓系细胞触发受体1、白细胞介素10的水平变化与相关性。方法:选取2014年6月—2015年9月本院ICU病房以重症肺炎为诊断收入院的患者86例,根据随机数字表法随机分为两组:对照组43例,予抗炎、化痰等常规治疗;实验组43例,在常规治疗基础上应用热毒宁注射液,共治疗7~10 d。观察两组患者治疗前后血浆可溶性髓系细胞触发受体1、白细胞介素10及血气分析等水平变化,探索热毒宁对重症肺炎患者的有效性及安全性,其数据结果应用统计学软件SPSS 19.0加以处理。结果:治疗前患者血清中s TREM-1和IL~(-1)0的浓度水平呈正相关(r=0.329,P=0.03),经1个疗程治疗后,与对照组比较,实验组患者血清中s TREM-1、IL~(-1)0浓度水平显著降低,体温、呼吸、白细胞降低,血氧分压及氧合指数明显升高,实验组的总有效率(90.70%)明显高于对照组(74.42%),以上结果均有统计学意义(P0.05)。实验组患者出现不良反应轻微,在停药后消失。结论:热毒宁能够减轻重症肺炎患者血清中炎症反应,改善临床症状体征,且安全性较高。
[Abstract]:Objective: To investigate the effect of Reduning on severe pneumonia in patients with plasma soluble triggering receptor 1, changes and correlation of 10 level interleukin. Methods: from June 2014 to September 2015 in our hospital ICU for diagnosis of severe pneumonia patients admitted to the hospital in 86 cases, according to the random number table method were randomly divided into two groups: control group 43 for example, anti-inflammatory, phlegm and other conventional treatment; 43 cases in the experimental group, the application of Reduning Injection on the basis of routine treatment, were treated with 7~10 D. were observed in two groups before and after treatment of plasma soluble triggering receptor 1, changes in the levels of interleukin 10 and blood gas analysis, to explore the efficacy and safety of Reduning on severe patients with pneumonia, the data using statistical software SPSS 19 to treatment. Results: before treatment, serum s TREM-1 and IL~ (-1) 0 concentration levels were positively related (r=0.329, P= 0.03), after 1 courses of treatment After treatment, compared with control group, the serum in the experimental group were s TREM-1, IL~ (-1) 0 concentration levels were significantly reduced, body temperature, respiration, leukopenia, PaO2 and oxygenation index increased significantly, the total efficiency of the experimental group (90.70%) was significantly higher than the control group (74.42%), the above results are statistical significance (P0.05). The patients in the experimental group appeared mild adverse reactions disappeared after stopping drug. Conclusion: Reduning can reduce inflammatory reaction in the serum of patients with severe pneumonia, improve the clinical symptoms and signs, and the safety is high.

【作者单位】：新乡医学院第一附属医院药学部;
【分类号】：R563.1
【正文快照】： 肺炎是严重危害人类健康的一种疾病[1],常由细菌、病毒等微生物感染所致,其死亡率在感染性疾病中排列首位。重症肺炎常由一般肺炎发展而来,其临床表现除咳嗽、咳痰、发热、呼吸困难等常见的呼吸系统症状外,还常伴有包括呼吸系统在内的多器官功能障碍。重症肺炎病情危重,是重症

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