酮替芬对变应性鼻炎-哮喘综合征呼出气一氧化氮的影响

发布时间：2018-02-14 14:52

本文关键词： 酮替芬变应性鼻炎-哮喘综合征呼出气一氧化氮白细胞介素-　出处：《临床耳鼻咽喉头颈外科杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的:研究酮替芬对变应性鼻炎-哮喘综合征患者呼出气一氧化氮(FeNO)的影响。方法:选取2016-01-2017-03期间治疗的84例支气管哮喘伴有变应性鼻炎患者,采用随机数字表分为观察组(42例)和对照组(42例)。对照组采用止咳、化痰、吸入激素平喘治疗,观察组在对照组基础上联用酮替芬(1mg/次,2次/d)口服处理,治疗1个月后对比分析2组患者FeNO、IL-17的变化情况。结果:治疗前,2组患者一般情况、FeNO测定结果差异无统计学意义(P0.05)。治疗后,观察组治疗有效率增高更明显(P0.05);2组FeNO、IL-17均降低(P0.05,P0.01),且观察组较对照组下降更明显,均差异有统计学意义(P0.01)。结论:酮替芬可明显降低变应性鼻炎-哮喘综合征患者的FeNO,降低气道炎症反应,其部分机制可能与降低炎症因子IL-17有关。
[Abstract]:Objective: To study the effect of ketotifen on allergic rhinitis and asthma syndrome of exhaled nitric oxide (FeNO) effect. Methods: 84 cases of bronchial asthma with allergic rhinitis patients selected during 2016-01-2017-03, were randomly divided into observation group (42 cases) and control group (42 cases) and control group. The cough, phlegm and asthma, inhaled corticosteroid therapy, the observation group in the control group combined with ketotifen (1mg/, 2 /d) oral treatment, compared 2 groups of patients with FeNO after 1 months of treatment, the changes of IL-17. Results: before treatment, 2 groups of patients in general, no statistical significance the test results of the FeNO difference (P0.05). After treatment, the treatment efficiency of observation group increased more significantly (P0.05); the 2 groups of FeNO, IL-17 were decreased (P0.05, P0.01), and the observation group decreased more significantly than the control group, the differences were statistically significant (P0.01). Conclusion: ketotifen significantly reduce allergic rhinitis FeNO in patients with asthma syndrome reduces airway inflammation, and some of the mechanisms may be associated with the reduction of inflammatory factor IL-17.

【作者单位】：华北理工大学附属医院呼吸科;
【基金】：2015年度河北省医学科学研究重点课题计划(No:20150535)
【分类号】：R562.25;R765.21

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