重要脏器纤维化病变治疗药物的研究进展

发布时间：2018-02-22 01:34

本文关键词： 纤维化肺纤维化肝硬化心脏肾药物治疗　出处：《中国药理学与毒理学杂志》2014年04期 　论文类型：期刊论文

【摘要】：纤维化是多种疾病的重要病理改变,其发病原因复杂,可导致正常组织功能的受损,甚至是丧失。尤其是重要脏器的纤维化严重影响患者生存质量,甚至危及生命,故针对不同脏器的纤维化治疗具有重要意义。不同器官纤维化发病原因不尽相同,但其基本机制是在炎症、免疫反应等刺激下,成纤维细胞增殖,导致胶原沉积。肝纤维化的治疗仍以中药为中心,重在缓解损伤,益气柔肝。由于目前尚无特效治愈肺纤维化的药物,故治疗仍以抗炎症为重点。肾纤维化的治疗主要针对缓解器质病变,改善肾功能而展开。虽然纤维化的治疗已取得了非常大的成果,但仍缺乏靶向性的药物。随着基因技术的发展,基因治疗也将成为疾病治疗的重要方向。本文综述了不同脏器纤维化的治疗药物,重点回顾了特异性作用于各脏器的药物。根据作用机制的不同,分类介绍了抗脏器纤维化的药物。
[Abstract]:Fibrosis is an important pathological change of many kinds of diseases, and its pathogenesis is complicated, which can lead to damage or even loss of normal tissue function. Especially, fibrosis of important organs seriously affects patients' quality of life and even endangers their lives. Therefore, the treatment of fibrosis in different organs is of great significance. The pathogenesis of fibrosis in different organs is different, but its basic mechanism is the proliferation of fibroblasts stimulated by inflammation, immune response, etc. Leading to collagen deposition. The treatment of liver fibrosis is still centered on traditional Chinese medicine, focusing on alleviating injury, benefiting qi and softening the liver. Because there is no special drug to cure pulmonary fibrosis, Therefore, the treatment is still focused on anti-inflammation. The treatment of renal fibrosis is mainly aimed at alleviating the pathological changes of the organ and improving the renal function. Although the treatment of fibrosis has made great achievements, With the development of gene technology, gene therapy will become an important direction of disease treatment. The specific drugs acting on various organs were reviewed, and the antifibrosis drugs were classified according to the mechanism of action.
【作者单位】：天津大学化工学院;军事医学科学院基础医学研究所;
【分类号】：R575.2;R563.9

【相似文献】