ADAM33基因S2位点多态性与支气管哮喘易感性关系的Meta分析

发布时间：2018-02-23 00:17

本文关键词： 哮喘解整合素金属蛋白酶基因多态性 Meta分析　出处：《现代预防医学》2014年05期 　论文类型：期刊论文

【摘要】：目的综合评价解整合素金属蛋白酶33(A Disintegrin and Metalloproteinase 33,ADAM33)基因S2位点多态性与哮喘易感性的关系。方法制定统一的检索策略,检索Pubmed、Ovid-Medline、Embase、CNKI、维普及万方数据库中有关ADAM33基因多态性与哮喘易感性关系的病例-对照研究,按照纳入和排除标准选择文献提取相关信息,应用Review Manager 5.0软件进行Meta分析。结果纳入10篇合格文献,均满足遗传平衡检验,累计哮喘2 798例和对照4 357例,其中亚洲哮喘患者1 604例,欧美哮喘患者1 194例。Meta分析结果显示,ADAM33基因S2位点显性模型(CC+CG vs.GG)合并OR值为1.56(95%CI:1.01～2.40,P=0.04),按种族分层分析,亚洲哮喘人群OR值为2.15(95%CI:1.00～4.70,P=0.05)。结论 ADAM33基因S2位点多态性与亚洲人发生哮喘的易感性升高有一定相关性。
[Abstract]:Objective to evaluate the relationship between S2 locus polymorphism of integrin metalloproteinase 33A Disintegrin and Metalloproteinase 33 and susceptibility to asthma. A case-control study on the association between ADAM33 gene polymorphism and asthma susceptibility was conducted in Pubmedus Ovid-Medlinea Embase CNKI, Weip and Wanfang databases. The relevant information was selected according to the inclusion and exclusion criteria. Meta analysis was carried out with Review Manager 5.0 software. Results the results showed that the genetic balance test was satisfied in 10 articles. The total number of asthma patients was 2 798 and the control was 4 357, including 1 604 asthmatic patients in Asia. Meta-analysis of 1 194 asthma patients in Europe and the United States showed that the dominant model of S 2 locus of ADAM33 gene (CC CG vs.GG) combined with OR value was 1.56 ~ 95% CI: 1.01 ~ 2.40% P0. 04%, analyzed by ethnic stratification. The OR value of Asian asthmatic population was 2.15 ~ 95% CI: 1.00 ~ 4.70%. Conclusion the S _ 2 locus polymorphism of ADAM33 gene is associated with the increased susceptibility of Asian people to asthma.
【作者单位】：新乡医学院公共卫生学院;驻马店市中心医院;
【基金】：河南省医学科技攻关计划项目(200803073) 驻马店市科技局资助项目(20602)
【分类号】：R562.25

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