不同浓度布地奈德联合复方异丙托溴铵对老年急性加重期慢性阻塞性肺疾病患者动脉血气及肺功能的影响

发布时间：2018-02-23 05:40

本文关键词： 布地奈德复方异丙托溴铵急性加重期慢性阻塞性肺疾病动脉血气肺功能　出处：《中国老年学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的探讨不同浓度布地奈德联合复方异丙托溴铵对老年急性加重期慢性阻塞性肺疾病(AECOPD)患者动脉血气及肺功能的影响。方法老年AECOPD患者60例,以随机数字表法分为小浓度组与大浓度组各30例。两组均采取常规对症治疗,在此基础上小浓度组应用小浓度布地奈德(2 mg/次,20 min/次,2次/d)雾化吸入联合复方异丙托溴铵治疗,大浓度组应用大浓度布地奈德(4 mg/次,20 min/次,2次/d)雾化吸入联合复方异丙托溴铵治疗,疗程均为1 w。观察对比两组临床疗效、治疗前后动脉血气、肺功能的变化及不良反应情况。结果大浓度组治疗的总有效率高于小浓度组(P0.05)。治疗1 w后,大浓度组血氧分压(PaO_2)高于小浓度组,二氧化碳分压(PaCO_2)低于小浓度组(均P0.05)。治疗1 w后,大浓度组1 s用力呼气容积(FEV1)、FEV1与用力肺活量比值(FEV1/FVC)均高于小浓度组(P0.05)。两组不良反应率比较差异无统计学意义(P0.05)。结论大浓度布地奈德联合复方异丙托溴铵治疗老年AECOPD患者具有显著的效果,可以改善患者的动脉血气及肺功能,安全性较好。
[Abstract]:Objective to investigate the effects of different concentrations of budesonide combined with compound ipratropium bromide on arterial blood gas and pulmonary function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Two groups were randomly divided into small concentration group (30 cases) and high concentration group (30 cases). Both groups were treated with routine symptomatic therapy. On the basis of this, the small concentration group was treated with small concentration budesonide 2 mg / time 20 min / d) nebulization combined with compound ipratropium bromide. The high concentration group was treated with budesonide 4 mg / d 20 min / d) atomization inhalation combined with compound ipratropium bromide for 1 w.The clinical efficacy of the two groups was observed and compared, and arterial blood gas was obtained before and after treatment. Results the total effective rate of the high concentration group was higher than that of the small concentration group (P 0.05). After 1 week of treatment, the blood oxygen partial pressure of the high concentration group was higher than that of the small concentration group. Paco _ 2 was lower than that in the low concentration group (P 0.05). After 1 week of treatment, Paco _ 2 was significantly lower than that in the low concentration group (P _ (0.05)). The ratio of FEV1 / FVC1 to forced vital capacity (FEV1 / FVC1) in the high concentration group was higher than that in the small concentration group (P 0.05). There was no significant difference in the adverse reaction rate between the two groups. Conclusion there is no significant difference in the adverse reaction rate between the two groups. Conclusion large concentration budesonide combined with compound isoprotopril bromide is effective in the elderly. Patients with AECOPD have significant effects. It can improve arterial blood gas and lung function of patients, and the safety is good.
【作者单位】：苏州大学附属无锡九院呼吸内科;
【基金】：2016年度无锡市科技发展指导性计划项目(No.CSZON1623)
【分类号】：R563.9

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