慢性阻塞性肺疾病急性加重期患者肺功能与病原菌感染及细胞因子相关性研究

发布时间：2018-03-02 19:50

本文选题：肺功能　切入点：病原菌感染　出处：《中华医院感染学杂志》2014年10期 　论文类型：期刊论文

【摘要】：目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者的肺功能与病原菌感染、细胞因子的相关性,以期为临床诊治提供依据。方法选取100例AECOPD患者进行肺功能测定,对痰液进行细菌培养,以双抗体夹心法检测痰液标本中的白细胞介素-8、白细胞介素-10、白细胞介素-19、肿瘤坏死因子-α的浓度。结果肺功能分级Ⅰ、Ⅱ、Ⅲ、Ⅳ级分别占6.00%、33.00%、47.00%、14.00%;有67例患者检出病原菌,阳性率67.00%,检出病原菌74株,其中革兰阴性菌占83.78%,革兰阳性菌占13.51%,真菌占2.70%;线性相关分析AECOPD患者不同肺功能分级与革兰阴性菌感染率间存在正相关(P0.05),不同肺功能分级与白细胞介素-8、白细胞介素-19、肿瘤坏死因子-α浓度间存在正相关(P0.05)。结论 AECOPD不同肺功能损伤程度阶段患者病原菌感染率及细胞因子浓度有所不同,以革兰阴性菌为主的细菌感染和细胞因子均参与了病程进展,导致患者气道炎症出现,引起肺功能下降。
[Abstract]:Objective to investigate the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) pulmonary function and pathogen infection, related cytokines, in order to provide the basis for clinical diagnosis and treatment. Methods 100 cases of AECOPD patients with lung function tests were conducted on sputum bacterial culture, with interleukin sputum test double antibody sandwich method the -8, interleukin -10, interleukin -19, tumor necrosis factor alpha concentration. The results of pulmonary function classification I, II, III, IV respectively 6%, 33%, 47%, 14%; 67 cases of pathogenic bacteria were detected, the positive rate was 67%, 74 strains of pathogens. The gram negative bacteria accounted for 83.78%, gram positive bacteria accounted for 13.51%, fungi accounted for 2.70%; the linear correlation analysis of different lung function in patients with AECOPD grade and gram negative bacteria infection rate between positive correlation (P0.05), different grade of pulmonary function and interleukin -8, interleukin -19, tumor There is a positive correlation between the concentration of tumor necrosis factor alpha (P0.05). Different rate and concentration of cytokine conclusion AECOPD the different degree of lung function impairment in patients with stage of pathogen infection, bacterial infection and cytokine of Gram-negative bacteria are involved in the progression of the disease, leading to airway inflammation, caused a decrease in lung function.

【作者单位】：浙江中医药大学附属第三医院体检中心;台州温岭东方医院内二科;浙江中医药大学附属第三医院保健科;
【基金】：浙江省卫生厅中医药研究基金项目(2009CA041)
【分类号】：R563.9

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