可溶性晚期糖基化终末产物受体在急性呼吸窘迫综合征患者诊断及预后评估中的应用价值

发布时间：2018-03-02 19:18

本文选题：呼吸窘迫综合征　切入点：成人　出处：《中国全科医学》2014年22期 　论文类型：期刊论文

【摘要】：目的探讨可溶性晚期糖基化终末产物受体(sRAGE)在急性呼吸窘迫综合征(ARDS)患者诊断及预后预测中的价值。方法选取2012年3月—2013年3月入住辽宁医学院附属第一医院重症监护病房的ARDS患者60例为ARDS组,根据氧合指数(PaO2/FiO2)将ARDS组分为轻度ARDS组(23例)、中度ARDS组(23例)及重度ARDS组(14例),根据预后分为死亡组(18例)及存活组(42例);另选择同时期入住重症监护病房的非ARDS患者60例为非ARDS组。采用酶联免疫吸附试验(ELISA)法检测患者血浆sRAGE水平,记录患者PaO2/FiO2。结果ARDS组较非ARDS组患者sRAGE水平升高,PaO2/FiO2降低,差异有统计学意义(P0.05)。不同严重程度ARDS组患者sRAGE水平及PaO2/FiO2比较,差异均有统计学意义(P0.05);其中中度ARDS组、重度ARDS组较轻度ARDS组,重度ARDS组较中度ARDS组患者sRAGE水平升高,PaO2/FiO2降低,差异有统计学意义(P0.05)。死亡组较存活组ARDS患者sRAGE水平升高,PaO2/FiO2降低,差异有统计学意义(P0.05)。直线相关性分析显示,ARDS组患者sRAGE水平与PaO2/FiO2呈负相关(r=-0.949,P=0.000 2)。结论 sRAGE在ARDS患者预后预测方面存在价值,可作为评价ARDS预后的一个生化标记物;在诊断方面可能存在一定价值,有待于进一步研究验证。
[Abstract]:Objective to investigate the value of soluble advanced glycosylation end product receptor (sRAGE) in the diagnosis and prognosis prediction of ARDS patients with acute respiratory distress syndrome. Methods the patients admitted to the first affiliated Hospital of Liaoning Medical College from March 2012 to March 2013 were admitted to the first affiliated Hospital of Liaoning Medical College. 60 patients with ARDS in the monitoring unit were treated with ARDS. According to oxygen index Pao _ 2 / FiO _ 2, ARDS group was divided into mild ARDS group (23 cases), moderate ARDS group (23 cases) and severe ARDS group (14 cases). According to prognosis, 14 cases were divided into death group (n = 18) and survival group (n = 42). The plasma sRAGE levels were detected by Elisa assay in 60 patients with non ARDS. Results Pao _ 2 / FiO _ 2 level in ARDS group was significantly higher than that in non-#en1# group, and the difference was statistically significant (P 0.05). There were significant differences in sRAGE level and PaO2/FiO2 in ARDS group with different severity (P 0.05). The level of sRAGE in severe ARDS group was higher than that in mild ARDS group, and that in severe ARDS group was higher than that in moderate ARDS group, the difference was statistically significant (P 0.05). The sRAGE level in death group was significantly higher than that in survival group, and Pao _ 2 / FiO _ 2 level in death group was lower than that in survival group. The linear correlation analysis showed that there was a negative correlation between sRAGE level and PaO2/FiO2 in patients with ARDS. Conclusion sRAGE is valuable in predicting the prognosis of ARDS patients and can be used as a biochemical marker for evaluating the prognosis of ARDS. There may be some value in diagnosis, which needs further study and verification.
【作者单位】：辽宁医学院附属第一医院重症医学科;
【基金】：辽宁省教育厅科学技术研究项目(2008419)
【分类号】：R563.8

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