竭泉饮联合胸腔生物化疗治疗恶性胸腔积液的临床观察

发布时间：2018-03-02 23:19

本文选题：恶性胸腔积液　切入点：竭泉饮　出处：《黑龙江中医药大学》2013年硕士论文　论文类型：学位论文

【摘要】：研究目的：观察竭泉饮联合胸腔生物化疗治疗恶性胸腔积液的临床疗效。研究方法：选择黑龙江中医药大学附属第一医院门诊和住院部符合纳入标准的饮停胸胁型恶性胸腔积液患者64例,随机分为两组,治疗组32例,对照组32例。治疗组脱落2例,对照组脱落2例。两组患者经B超定位后,局部利多卡因麻醉,胸腔内置管,将胸腔积液尽量抽尽,首次抽液者抽液600ml,以后每次不超过1000ml,予以胸腔内注入生理盐水20ml+力尔凡50mg,隔一天一次,共三次,第七天胸腔内注入生理盐水20ml+顺铂80mg。治疗组同时口服竭泉饮,由我院中药制剂室统一煎制,真空包装,每袋150ml,300ml早晚分服,连续服用5周为一疗程。重点观察两组近期疗效,中医证候学疗效,生活质量,随访6个月胸水复发率比较等指标。研究结果： 1.近期疗效：治疗组CR3例,PR23例,SD3例,PD1例,无病情加重患者,缓解率为86.7%。对照组CR0例,PR16例,SD9例,PD5例,无病情加重患者,缓解率为55.2%。两组间有统计学差异(P0.05)。 2.中医证候疗效：治疗组临床痊愈4例,显效3例,有效20例,无效3例,总有效率为90%。对照组临床痊愈1例,显效3例,有效13例,无效13例,总有效率为56.67%。两组间有统计学差异(P0.05)。 3.6个月疗效：观察胸水复发增长情况,两组间有统计学差异(P0.05)。 4.生活质量评分：治疗组治疗前后具有显著性差异(P0.01)。 5.毒副反应比较：两组治疗前后比较均无统计学意义(P0.05)。结论： 1.竭泉饮联合胸腔生物化疗治疗恶性胸腔积液具有明显疗效； 2.竭泉饮联合胸腔生物化疗对中医证候具有明显改善作用； 3.竭泉饮联合胸腔生物化疗对生活质量具有显著改善作用； 4.竭泉饮联合胸腔生物化疗试验期间毒副反应较轻。
[Abstract]:Objective: To observe the clinical effect of the treatment of malignant pleural effusion with the combined thoracic cavity biologic chemotherapy.
Research methods: the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine outpatient and inpatient department in accordance with the inclusion criteria of 64 cases of chest and hypochondrium Yin type malignant pleural effusion were randomly divided into two groups, 32 cases in the treatment group, 32 cases in the control group. The treatment group 2 cases were lost and the control group. 2 cases. Two groups of patients by ultrasound localization, local lidocaine anesthesia, intrapleural catheter, pleural effusion was aspirated completely for the first time, pumping liquid liquid extraction 600ml, after no more than 1000ml, to be the intrapleural injection of 20ml+ saline lifein 50mg, once every other day, a total of three times, seventh days of intrapleural injection of 20ml+ saline treatment group and cisplatin 80mg. an oral spring drink by traditional Chinese medicine preparation in our hospital room, unified fried, vacuum packaging, each bag is 150ml 300ml, sooner or later the service, taking 5 consecutive weeks as a course of treatment. Observe two groups of curative effect, TCM syndrome curative effect, quality of life, after 6 months of follow-up chest water complex Rate comparison and other indicators.
The results of the study:
1., short-term efficacy: treatment group CR3 cases, PR23 cases, SD3 cases, PD1 cases, no exacerbation of patients, the remission rate is 86.7%. control group CR0 cases, PR16 cases, SD9 cases, PD5 cases, no exacerbation of patients, the remission rate is 55.2%., there is a significant difference between the two groups (P0.05).
2., the efficacy of TCM syndrome: the treatment group was cured in 4 cases, markedly effective in 3 cases, effective in 20 cases, ineffective in 3 cases, the total effective rate was 90%.. In the control group, 1 cases were cured, 3 cases were markedly effective, 13 cases were effective, 13 cases were ineffective, the total effective rate was 56.67%., and there was a significant difference between two groups (P0.05).
3.6 months of curative effect: To observe the recurrence of hydrothorax, and there was a statistical difference between the two groups (P0.05).
4. quality of life score: there was a significant difference in the treatment group before and after treatment (P0.01).
The comparison of 5. toxic and side effects: there was no significant difference between the two groups before and after treatment (P0.05).
Conclusion:
1. exhausted spring drink combined with thoracic cavity biologic chemotherapy is effective in the treatment of malignant pleural effusion.
2. Qi Quan drink combined with thoracic cavity biologic chemotherapy has an obvious effect on TCM syndrome.
3. Qi Quan drink combined with thoracic cavity biologic chemotherapy has a significant improvement on the quality of life.
The toxic side effects of the 4. exhausted spring drink combined with the pleural chemo chemotherapy test were mild.

【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R561.3

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